Highly divergent gene expression programs can lead to similar chordate larval body plans

Current Biology : CB
Daniel SobralPatrick Lemaire

Abstract

The diversity of animal morphologies is thought to result largely from spatial or temporal variations in gene expression. Conversely, we explored here the extent of divergence in transcriptional expression patterns compatible with a common morphological output, the chordate larva. We compared two organisms that share a prototypical tadpole larval body plan but are separated by over half a billion years of divergent evolution: the zebrafish (Danio rerio) and the ascidian Ciona intestinalis, an invertebrate chordate belonging to the sister group of vertebrates. The large databases of whole-mount in situ hybridization expression patterns available for these two species allowed us to carry out a systematic large-scale comparison of spatiotemporal expression patterns of 1103 groups of orthologous genes. We found an extensive overall divergence in gene expression profiles between the two species that was similar at all developmental stages and did not discriminate developmental regulators from their targets. The level of conservation in individual tissues, however, varied. Conservation of tissue-specific expression patterns was highest in tissues involved in locomotion, including muscle, notochord, and the central nervous system. Thu...Continue Reading

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Citations

Jul 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Brian P PiaseckiPeter Swoboda
May 4, 2010·The Plant Cell·Idan EfroniEliezer Lifschitz
Nov 28, 2013·PLoS Genetics·Laura DoglioGreg Elgar
Nov 13, 2014·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Sophie Pantalacci, Marie Sémon
Nov 14, 2014·Genesis : the Journal of Genetics and Development·Quirino Attilio VassalliAnnamaria Locascio
Feb 18, 2011·Transcription·Tamar Hashimshony, Itai Yanai
May 9, 2012·Developmental Cell·Michal LevinItai Yanai
May 21, 2013·Developmental Biology·Olivier ArmantSepand Rastegar
Jun 22, 2016·Wiley Interdisciplinary Reviews. Developmental Biology·Clare Hudson
Nov 6, 2020·Science Advances·Tengjiao ZhangZhirong Bao
Mar 24, 2011·Development·Clare HudsonHitoyoshi Yasuo
May 12, 2011·Development·Patrick Lemaire
Dec 24, 2018·Developmental Biology·Luca AmbrosinoAnnamaria Locascio

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