Highly effective Cu/Zn-carbon micro/nanofiber-polymer nanocomposite-based wound dressing biomaterial against the P. aeruginosa multi- and extensively drug-resistant strains

Materials Science & Engineering. C, Materials for Biological Applications
Mohammad AshfaqSuphiya Khan

Abstract

Pseudomonas aeruginosa (P. aeruginosa) is the most prevalent bacteria in the infections caused by burn, surgery, and traumatic injuries. Emergence of the P. aeruginosa bacterial resistance against various clinical drugs for wound treatment is the major concern nowadays. The present study describes the synthesis of the polyvinyl alcohol (PVA) and cellulose acetate phthalate (CAP) polymeric composite film (~0.2mm thickness) reinforced with the Cu/Zn bimetal-dispersed activated carbon micro/nanofiber (ACF/CNF), as a wound dressing material. The focus is on determining the efficacy of the prepared biomaterial against the multi and extensively drug-resistant P. aeruginosa strains isolated from the burning, surgical, and traumatic injury-wounds. The primary synthesis steps for the biomaterial include the mixing of a blend of CAP powder and the asymmetrically distributed Cu/Zn bimetals in ACF/CNF, into the polymerization reaction mixture of PVA. Biochemical tests showed that the prepared composite material significantly enhanced the in-vitro blood clotting rate, platelet aggregation, and macrophage cell proliferation, indicating the suitability of the material as a fast wound healer. The antibacterial tests performed against the P. ae...Continue Reading

Citations

Nov 20, 2018·Journal of Biomaterials Science. Polymer Edition·Hui YuPeifeng Liu
Jul 17, 2020·Frontiers in Chemistry·Naman AroraGeorgios N Karanikolos
Jan 26, 2021·International Journal of Pharmaceutics·Tahereh MirmajidiAli Mohammad Sharifi
Mar 23, 2021·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Ghada G AbdoAhmed A Elzatahry
Aug 19, 2021·Macromolecular Bioscience·Fengze MiaoQuangang Zhu

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