Highly effective induction therapy for stage 4 neuroblastoma in children over 1 year of age

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
B H KushnerN K Cheung

Abstract

To test the efficacy of a protocol for poor-risk neuroblastoma that builds on the following: (1) our favorable previously reported results with dose-intensive use of cyclophosphamide; (2) our retrospective analysis of neuroblastoma chemotherapy reports, which supported the value of high-dose cisplatin and etoposide (VP-16); and (3) the Goldie-Coldman hypothesis that rapid cytoreduction plus the use of non-cross-resistant chemotherapy combinations will decrease the risk of drug resistance. The N6 protocol included seven courses of high-dose chemotherapy plus surgical resection of bulk disease. Courses 1, 2, 4, and 6 consisted of 6-hour intravenous infusions of cyclophosphamide 70 mg/kg/d on days 1 and 2 (ie, 140 mg/kg per course), a 72-hour intravenous infusion of doxorubicin 75 mg/m2 and vincristine 0.1 mg/kg beginning day 1, and vincristine 1.5 mg/m2 intravenous bolus on day 9. Courses 3, 5, and 7 consisted of 2-hour intravenous infusions of VP-16 200 mg/m2/d on days 1 to 3 (ie, 600 mg/m2 per course), and 1-hour intravenous infusions of cisplatin 50 mg/m2/d on days 1 to 4 (ie, 200 mg/m2 per course). Courses were to start after neutrophil counts reached 500/microL and platelet counts reached 100,000/microL. Response was defined...Continue Reading

Citations

Mar 8, 2000·Proceedings of the National Academy of Sciences of the United States of America·M D MegonigalC A Felix
Nov 7, 2000·Cancer·I J DunkelD H Abramson
Jul 24, 2001·Medical and Pediatric Oncology·D A TweddleA D Pearson
May 30, 2003·The Oncologist·Joanna L WeinsteinSusan L Cohn
Jun 28, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Katherine K MatthayJean Michon
Nov 5, 2003·Medical and Pediatric Oncology·Brian H KushnerNai-Kong V Cheung
Dec 8, 2005·Pediatric Blood & Cancer·Henrik SchroederPeter Hokland
Nov 2, 2007·Pediatric Blood & Cancer·Suzanne L WoldenNai-Kong V Cheung
Dec 18, 2007·Expert Reviews in Molecular Medicine·Erik JohnsonPaul M Sondel
Jun 1, 2012·Critical Reviews in Clinical Laboratory Sciences·Cormac Owens, Meredith Irwin
Feb 19, 2014·Pediatric Blood & Cancer·Alberto Garaventa
Oct 3, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B H KushnerN K Cheung
Dec 16, 1998·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·S WilliamsJ J Jenkins
Sep 7, 2002·Cancer·Brian H KushnerNai-Kong V Cheung
Feb 19, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Leigh HaysomGad Kainer
Apr 23, 2010·Expert Opinion on Pharmacotherapy·Rani E GeorgeMark L Bernstein
Dec 1, 2012·Case Reports in Oncological Medicine·Samin AlaviMohammad Taghi Arzanian
Jan 15, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Wendy LandierSmita Bhatia
Nov 6, 2014·Molecular Medicine Reports·Mohamad H DarwishHassan R Dhaini
Mar 5, 2016·Expert Review of Clinical Pharmacology·Jaume Mora
Jan 5, 2018·Oncotarget·Ingo LangeDana-Lynn T Koomoa
Jul 28, 2019·Medicine·Yan-Bin TanRun-Lin Yang
May 10, 2020·JAMA Network Open·Kelly R McMahonUNKNOWN Applying Biomarkers to Minimize Long-term Effects of Childhood/Adolescent Cancer Treatment (ABLE) Research Study Group
Feb 16, 1999·Seminars in Surgical Oncology·G M HaaseJ B Atkinson
Oct 27, 2006·Pediatric Blood & Cancer·Peter J HoughtonMalcolm A Smith
Jul 16, 2005·Pediatric Hematology and Oncology·Jairam Sastry, Stewart J Kellie
Feb 2, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D FrappazJ M Zucker
Apr 22, 2006·Pediatric Blood & Cancer·Natia EsiashviliPeter A S Johnstone
Jan 26, 2007·Pediatric Blood & Cancer·J A KohlerUNKNOWN Neuroblastoma Working Group of the Children's Cancer and Leukaemia Group
Jan 22, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dominique Valteau-CouanetOlivier Hartmann
May 19, 2005·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Victoria CastelUNKNOWN Grupo Español de Neuroblastoma (SEOP)
Oct 20, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Julie R ParkKatherine K Matthay
Aug 24, 2013·Pediatric Blood & Cancer·Dominique Valteau-CouanetOlivier Hartmann
Jul 27, 2012·Future Oncology·Jennifer GainsMark Gaze

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