Highly efficient asymmetric aldol reaction in brine using a fluorous sulfonamide organocatalyst

Organic & Biomolecular Chemistry
Tsuyoshi MiuraAkichika Itoh

Abstract

A fluorous organocatalyst promotes direct asymmetric aldol reactions of aromatic aldehydes with ketones in brine to afford the corresponding anti-aldol products in high yield with up to 96% ee. Fluorous organocatalyst can be readily recovered by solid phase extraction using fluorous silica gel and reused without purification.

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Citations

Nov 30, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kosuke NakashimaTsuyoshi Miura
Apr 11, 2017·The Journal of Organic Chemistry·Takaaki SakaiTsuyoshi Miura
Sep 9, 2016·Organic & Biomolecular Chemistry·Veeramanoharan AshokkumarAyyanar Siva
Oct 12, 2013·Chemistry : a European Journal·Ulf Scheffler, Rainer Mahrwald

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