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Highly-efficient Cas9-mediated transcriptional programming

bioRxiv

Dec 20, 2014

Alejandro ChavezGeorge M. Church

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Abstract

The RNA-guided bacterial nuclease Cas9 can be reengineered as a programmable transcription factor by a series of changes to the Cas9 protein in addition to the fusion of a transcriptional activation domain (AD). However, the modest levels of gene activation achieved by current Cas9 acti...read more

Mentioned in this Paper

Gene Activation
Nuclease
Cell Differentiation Process
Transcription Factor
Induced Pluripotent Stem Cells
Neuronal
Transcriptional Activation Domain
Transcription, Genetic
53
1
1
4
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  • Highly-efficient Cas9-mediated transcriptional programming

    bioRxiv

    Dec 20, 2014

    Alejandro ChavezGeorge M. Church

    PMID: 990012880

    DOI: 10.1101/012880

    Abstract

    The RNA-guided bacterial nuclease Cas9 can be reengineered as a programmable transcription factor by a series of changes to the Cas9 protein in addition to the fusion of a transcriptional activation domain (AD). However, the modest levels of gene activation achieved by current Cas9 acti...read more

    Mentioned in this Paper

    Gene Activation
    Nuclease
    Cell Differentiation Process
    Transcription Factor
    Induced Pluripotent Stem Cells
    53
    1
    1
    4
    Paper Details
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