Highly efficient chemoenzymatic synthesis of beta1-4-linked galactosides with promiscuous bacterial beta1-4-galactosyltransferases.

Chemical Communications : Chem Comm
Kam LauXi Chen

Abstract

Two bacterial beta1-4-galactosyltransferases, NmLgtB and Hp1-4GalT, exhibit promiscuous and complementary acceptor substrate specificity. They have been used in an efficient one-pot multienzyme system to synthesize LacNAc, lactose, and their derivatives including those containing negatively charged 6-O-sulfated GlcNAc and C2-substituted GlcNAc or Glc, from monosaccharide derivatives and inexpensive Glc-1-P.

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Citations

Aug 23, 2011·Nature Chemical Biology·Richard W GanttJon S Thorson
Aug 25, 2011·Chemical Communications : Chem Comm·Yi ChenXi Chen
Oct 20, 2011·Molecular BioSystems·Yiyan FeiXiangdong Zhu
Feb 22, 2011·Current Opinion in Chemical Biology·Monica M Palcic
Jun 16, 2016·The Journal of Organic Chemistry·Zhongying XiaoPeng George Wang
Jul 14, 2016·Chemical Reviews·Marco MendeStefan Bräse
Dec 14, 2016·Carbohydrate Research·Dawa TseringHongzhi Cao
Feb 1, 2017·Chemical Science·Abhishek SantraXi Chen
Feb 18, 2016·Organic & Biomolecular Chemistry·Hai Yu, Xi Chen
Feb 25, 2018·Applied Microbiology and Biotechnology·Rachel Chen
Oct 28, 2016·Chemical Communications : Chem Comm·Y SunM Nitz
Jun 24, 2015·Chemical Communications : Chem Comm·Yan ZhangHongzhi Cao
May 8, 2018·Angewandte Chemie·Shuaishuai WangLei Li
Apr 8, 2015·Chemical Communications : Chem Comm·Congcong ChenHongzhi Cao
May 24, 2018·Organic & Biomolecular Chemistry·Hai YuXi Chen
May 29, 2018·Angewandte Chemie·Caicai MengHongzhi Cao
May 14, 2017·Biology Open·Ruben T Almaraz, Yanhong Li
Dec 1, 2011·Angewandte Chemie·Che-Hsiung HsuChi-Huey Wong
Jun 6, 2019·Organic & Biomolecular Chemistry·Kun HuangSabine L Flitsch
Nov 16, 2019·International Journal of Molecular Sciences·Johannes GottschalkLothar Elling
Aug 22, 2017·European Journal of Organic Chemistry·Yunpeng LiuJunqiang Fang
Sep 1, 2012·Current Protocols in Chemical Biology·Hai YuXi Chen
Feb 18, 2015·Chemical Communications : Chem Comm·Musleh M MuthanaXi Chen
Jun 25, 2020·Chemical Communications : Chem Comm·Congcong ChenHongzhi Cao
Oct 31, 2018·Angewandte Chemie·Jiabin ZhangPeng G Wang
Nov 5, 2017·Metabolic Engineering·Timothy G KeysMarkus Aebi
May 18, 2021·Frontiers in Molecular Biosciences·Shuaishuai WangLei Li

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