Highly efficient drug delivery systems based on functional supramolecular polymers: In vitro evaluation

Acta Biomaterialia
Chih-Chia ChengDuu-Jong Lee

Abstract

The novel concept of modifying and enhancing the properties of existing functional micelles through self-complementary interactions has significant potential. In this study, a practical approach to living polymerization of functionalized thermoresponsive monomers enabled the incorporation of self-constituted multiple hydrogen bonded groups into micelles that have potential as supramolecular drug-delivery systems. Phase transitions and morphological studies in aqueous solution showed that the microstructure can be controlled to achieve well-defined vesicle-like micelles with respect to the strength of the hydrogen bond segment. Thus, the resulting micelles have a very low critical micellization concentration and very high loading capacity (16.1%), making the loading process extremely stable and efficient. Incorporation of the anticancer drug doxorubicin (DOX) affected the micellization process in aqueous solution and enabled fine-tuning of drug loading and precise control of drug release rate with excellent sensitivity. Release studies in vitro showed that DOX-loaded micelles exerted dose-dependent cytotoxicity against human liver carcinoma (HepG2) cells at the physiological temperature of 37°C. In addition, DOX-loaded micelles ...Continue Reading

References

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Citations

Sep 2, 2020·Macromolecular Bioscience·Fasih Bintang IlhamiChih-Chia Cheng
Mar 22, 2018·Signal Transduction and Targeted Therapy·Sudipta SenapatiPralay Maiti
Jul 8, 2020·International Journal of Molecular Sciences·Yihalem Abebe AlemayehuChih-Chia Cheng
Dec 31, 2020·International Journal of Molecular Sciences·Fasih Bintang IlhamiChih-Chia Cheng
Dec 12, 2017·Nano Today·Shabir HassanAli Khademhosseini
Oct 14, 2018·Advanced Drug Delivery Reviews·Alexandre BordatNicolas Tsapis
Jul 6, 2021·Frontiers in Pharmacology·Jiayi ChenGang Chen
Jan 20, 2021·ACS Biomaterials Science & Engineering·Chih-Chia ChengJuin-Yih Lai

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