Highly efficient photocontrolled targeted delivery of siRNA by a cyclodextrin-based supramolecular nanoassembly

Chemical Communications : Chem Comm
Feng-Qing LiYu Liu

Abstract

In this study, we have constructed a binary supramolecular nanoassembly composed of α-cyclodextrin-modified hyaluronic acid and an azobenzene-modified diphenylalanine derivative with a positively charged imidazole group. This nanoassembly can bind with siRNA through electrostatic interactions and efficiently delivered them into cancer cells and inhibited their growth.

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Methods Mentioned

BETA
transfection
transmission electron microscopy
scanning electron microscopy
NMR

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