Highly efficient synthesis of HIV NNRTI doravirine

Organic Letters
Donald R GauthierDavid M Tschaen

Abstract

The development of an efficient and robust process for the production of HIV NNRTI doravirine is described. The synthesis features a continuous aldol reaction as part of a de novo synthesis of the key pyridone fragment. Conditions for the continuous flow aldol reaction were derived using microbatch snapshots of the flow process.

References

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Citations

Jun 8, 2017·Organic Letters·Abdellatif ElMarrouniAntonella Converso
Mar 14, 2019·Mini Reviews in Medicinal Chemistry·Suvarna G KiniVaradaraj Bhat
May 18, 2019·Chemistry : a European Journal·Haibo MeiVadim A Soloshonok
Jul 3, 2018·Journal of Chromatography. a·Jinjian ZhengSimon Wang
Jun 18, 2021·Beilstein Journal of Organic Chemistry·Guido GambacortaIan R Baxendale
May 30, 2019·The Journal of Organic Chemistry·Daniel D Caspi, Steven M Richter
Apr 28, 2020·Journal of Medicinal Chemistry·Andrew C FlickChristopher J O'Donnell

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