Highly efficient water-mediated approach to access benzazoles: metal catalyst and base-free synthesis of 2-substituted benzimidazoles, benzoxazoles, and benzothiazoles

Molecular Diversity
Manju BalaBikram Singh

Abstract

An efficient water-catalyzed method has been developed for the synthesis of 2-substituted benzimidazoles, benzoxazoles, and benzothiazoles in one step. The present method excludes the usage of toxic metal catalysts and bases to produce benzazoles in good to excellent yields. An efficient and versatile water-mediated method has been established for the synthesis of various 2-arylbenzazoles. The present protocol excludes the usage of any catalyst and additive provided excellent selectivities and yields with high functional group tolerance for the synthesis of 2-arylated benzimidazoles, benzoxazoles, and benzothiazoles. Benzazolones were also synthesized using similar reaction protocol.

References

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Citations

Jul 13, 2018·Journal of the American Chemical Society·Peter J WallerOmar M Yaghi
Mar 28, 2018·Journal of the American Chemical Society·Pi-Feng WeiWei Wang
Jul 3, 2019·Journal of the American Chemical Society·Steven J LyleOmar M Yaghi

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