Highly elevated soluble Tim-3 levels correlate with increased hepatocellular carcinoma risk and poor survival of hepatocellular carcinoma patients in chronic hepatitis B virus infection

Cancer Management and Research
Fang LiZhengwen Liu

Abstract

Upregulated T-cell immunoglobulin and mucin domain containing molecule-3 (Tim-3) in hepatitis B virus (HBV)-specific CD8+ T-cells contributes to CD8+ T-cell exhaustion during chronic HBV infection. The membrane-bound Tim-3 can be cleaved from the cell surface by sheddase, yielding soluble Tim-3 (sTim-3). This study investigated serum sTim-3 levels in patients with chronic HBV infection of various liver diseases. Serum sTim-3 levels were quantitatively determined in 288 patients with chronic HBV infection of various liver diseases. The sTim-3 levels were analyzed in relation to liver diseases including HBV-related hepatocellular carcinoma (HCC) and overall survival of HCC patients. Serum sTim-3 levels in the patients with chronic HBV infection were significantly elevated compared with healthy controls (P<0.001) and the levels from asymptomatic HBV carrier status, chronic hepatitis, liver cirrhosis to HCC were progressively increased. Serum sTim-3 levels were closely associated with the severity of liver function abnormalities. Importantly, serum sTim-3 levels were independently associated with HCC risk (OR, 4.310; 95% CI, 2.141-8.676, P<0.001) in comparison to non-HCC diseases in chronic HBV infection and significantly associate...Continue Reading

Citations

Sep 6, 2019·Scandinavian Journal of Immunology·Lizhen ZhaoBei Zhang
Feb 23, 2020·Journal of Clinical Laboratory Analysis·Ming ChenZhigang Hu
Oct 13, 2018·Journal of Hematology & Oncology·Feifei LiuZhi Chen
Dec 4, 2019·Frontiers in Immunology·Meijuan Zheng, Zhigang Tian
Jul 29, 2019·Hepatology International·Lifeng Wang, Fu-Sheng Wang
Mar 12, 2020·Oncogene·David J PinatoLorenza Rimassa
Mar 30, 2021·World Journal of Gastroenterology : WJG·Byung Min Lee, Jinsil Seong
Jun 4, 2020·Cellular Oncology (Dordrecht)·Łukasz ZadkaPiotr Dzięgiel
Aug 7, 2021·The Journal of Biological Chemistry·Rajesh Abraham JacobJimmy D Dikeakos

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
enzyme-linked immunosorbent assay
ELISA
PCR

Software Mentioned

SPSS

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.