Highly enantioselective Michael addition reactions of 2-substituted benzofuran-3(2H)-ones to nitroolefins

Organic & Biomolecular Chemistry
Zhi-Pei ZhangJin-Pei Cheng

Abstract

A highly enantioselective Michael addition reaction of 2-substituted benzofuran-3(2H)-ones to nitroolefins was promoted by a bifunctional squaramide catalyst. As a result, a number of chiral 2,2'-substituted benzofuran-3-one derivatives, bearing adjacent quaternary-tertiary stereocenters, were efficiently synthesized with excellent enantioselectivities.

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Citations

May 31, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Diego A AlonsoDiego J Ramón
Jul 23, 2019·Organic & Biomolecular Chemistry·Koilpitchai Sivamuthuraman, Venkitasamy Kesavan
Oct 31, 2018·Organic Letters·Petra VojáčkováJakub Švenda
Jul 4, 2018·The Journal of Organic Chemistry·Koilpitchai Sivamuthuraman, Venkitasamy Kesavan

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