Highly expressed dectin-1 on bone marrow-derived dendritic cells regulates the sensitivity to beta-glucan in DBA/2 mice

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
Toshie HaradaNaohito Ohno

Abstract

Sparassis crispa beta-glucan (SCG) is a major six-branched 1,3-beta-D-glucan in S. crispa Fr. showing antitumor activity. We previously found that DBA/1 and DBA/2 mice are highly sensitive to SCG in vivo and in vitro. In this study, we investigated the effect of SCG on bone marrow-derived dendritic cells (BMDCs) in DBA/2 mice in vitro. SCG increased the expression of CD80, MHC class I and MHC class II molecules on the cell membrane of BMDCs. SCG induced BMDCs to produce interleukin-12p70 (IL-12p70), IL-6, and tumor necrosis factor-alpha (TNF-alpha). The magnitude of cytokine induction by SCG in DBA/2 mice was higher than that in C57BL/6, BALB/c, C3H/HeN, and C3H/HeJ mice. The expression level of the beta-glucan receptor, dectin-1, on BMDCs in DBA/2 mice was also highest in DBA/2 among these mice. Blocking dectin-1 significantly inhibited the induction of TNF-alpha production by SCG. Taken together, these results suggest that the BMDCs from DBA/2 mice are highly sensitive to the induction of cytokine production by SCG in vitro, and that this sensitivity is related to the expression level of dectin-1.

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Citations

Nov 10, 2010·Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology·Toshie HidaNaohito Ohno
Dec 1, 2011·Immunopharmacology and Immunotoxicology·Daisuke YamanakaNaohito Ohno
Aug 11, 2012·International Immunopharmacology·Daisuke YamanakaNaohito Ohno
Aug 12, 2010·International Immunopharmacology·Hyung Sook KimSang-Bae Han
Dec 19, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hyung Sook KimSang-Bae Han
Apr 24, 2010·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S FukahoriS Kohno
Sep 14, 2020·Allergology International : Official Journal of the Japanese Society of Allergology·Takashi KannoNaohito Ohno
May 7, 2021·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Naohito Ohno

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