Highly flexible and degradable dual setting systems based on PEG-hydrogels and brushite cement

Acta Biomaterialia
Michaela RödelUwe Gbureck

Abstract

With respect to the composition of natural bone, we established a degradable dual setting system of different poly(ethylene glycol) (PEG)-based hydrogels combined with a brushite cement. The idea was to reinforce the inorganic calcium phosphate mineral phase with an organic, polymeric phase to alter the cement's properties towards ductility and elasticity. Extremely flexible samples were produced via this dual setting approach with a fully reversible elasticity of the samples containing high molecular weight PEG-based hydrogel precursors. Using the decalcifying agent EDTA, the whole inorganic phase was dissolved due to Ca2+-complexation and dimensionally stable hydrogels were obtained, indicating a homogenous polymeric phase within the composites. This was also confirmed by SEM-analysis, where no discontinuities or agglomerations of the phase were observed. Additional XRD-measurements proved a significant influence of the coherent polymeric matrix on the conversion from β-TCP/MCPA to brushite with a decrease in signal intensity. The results confirmed a parallelly running process of setting reaction and gelation without an inhibition of the conversion to brushite and the formation of interpenetrating networks of hydrogel and cem...Continue Reading

Citations

Jul 30, 2019·Advanced Healthcare Materials·Yanran ZhaoZhenzhong Yang
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Claudia MorillaLuis J Cruz
Aug 5, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Luguang DingBin Li
Jun 28, 2019·ACS Applied Materials & Interfaces·Daniela-Geta PetreSander C G Leeuwenburgh

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