Highly homologous hS100A15 and hS100A7 proteins are distinctly expressed in normal breast tissue and breast cancer.

Cancer Letters
Ronald WolfStuart H Yuspa

Abstract

Human S100A7 (psoriasin) is considered a marker for specific stages of breast cancer. hS100A15 is almost identical to hS100A7 and difficult to discriminate. We developed specific probes to distinguish hS100A7 and hS100A15, and demonstrate their differential distribution in normal breast tissue. Further, hS100A7 and S100A15 transcripts are elevated in ER/PR negative breast cancers, but hS100A15 protein is detected in all cancer specimens while hS100A7 protein is sporadically expressed. The differential regulation, expression and distribution of hS100A7 and hS100A15 and their reported distinct functions are compelling reasons to discriminate among these proteins in normal breast and breast cancers.

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Citations

Dec 15, 2010·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Eadaoin McKiernanMichael J Duffy
Dec 15, 2010·Science Translational Medicine·Ronald WolfStuart H Yuspa
Dec 14, 2011·Cancer Research·Mohd W NasserRamesh K Ganju
Jul 17, 2012·Journal of Dermatological Science·Jason Winston, Ronald Wolf
Nov 22, 2011·Journal of Inorganic Biochemistry·P D DarbreF Mannello
Feb 14, 2013·Genes, Chromosomes & Cancer·Francesca MicciSverre Heim
Apr 20, 2011·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Regine GläserJürgen Harder
May 15, 2013·Current Opinion in Pharmacology·Eva HattingerRonald Wolf
Mar 31, 2015·Indian Journal of Cancer·F LiW Zhang
Feb 13, 2019·Asian-Australasian Journal of Animal Sciences·Soohyung LeeHakhyun Ka

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