Highly Hydrophilic Luminescent Magnetic Mesoporous Carbon Nanospheres for Controlled Release of Anticancer Drug and Multimodal Imaging

Langmuir : the ACS Journal of Surfaces and Colloids
Smruti R RoutSasmita Mohapatra

Abstract

Judicious combination of fluorescence and magnetic properties along with ample drug loading capacity and control release property remains a key challenge in the design of nanotheranostic agents. This paper reports the synthesis of highly hydrophilic optically traceable mesoporous carbon nanospheres which can sustain payloads of the anticancer drug doxorubicin and T2 contrast agent such as cobalt ferrite nanoparticles. The luminescent magnetic hybrid system has been prepared on a mesoporous silica template using a resorcinol-formaldehyde precursor. The mesoporous matrix shows controlled release of the aromatic drug doxorubicin due to disruption of supramolecular π-π interaction at acidic pH. The particles show MR contrast behavior by affecting the proton relaxation with transverse relaxivity (r2) 380 mM(-1) S(-1). The multicolored emission and upconversion luminescence property of our sample are advantageous in bioimaging. In vitro cell experiments shows that the hybrid nanoparticles are endocyted by the tumor cells through passive targeting. The pH-responsive release of doxorubicin presents chemotherapeutic inhibition of cell growth through induction of apoptosis.

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Citations

Aug 19, 2017·Nanoscale·Yao-Wen JiangFu-Gen Wu
May 28, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Qianqian ZhangYaming Zhou
Mar 29, 2020·Topics in Current Chemistry·María Díaz-GonzálezJose Manuel Costa-Fernandez
Mar 13, 2018·Beilstein Journal of Nanotechnology·Nagamalai VasimalaiMaría Teresa Fernández-Argüelles
Sep 28, 2017·Bioengineering·Miguel Gisbert-GarzaránMaría Vallet-Regí
May 6, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Snigdharani PandaSasmita Mohapatra
Jul 16, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Albert SerràElvira Gómez
May 29, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Liwei WangLixiong Zhang
Mar 7, 2020·ACS Applied Materials & Interfaces·Miguel Gisbert-GarzaránMaría Vallet-Regí
Nov 15, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Ali PourjavadiMehdi Akhlaghi

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