Highly increased TNF sensitivity of tumor cells expressing the yeast delta 9-desaturase gene

Biochemical and Biophysical Research Communications
Z GyörfyE Duda

Abstract

L929 and WEHI tumor cell lines were genetically modified to constitutively express the Saccharomyces cerevisiae Ole 1 gene, coding for the delta 9-desaturase enzyme. These cells exhibit an increased ratio of monounsaturated fatty acids in their membrane phospholipids paralleled by an overall decrease in the membrane molecular order and a highly increased tumor necrosis factor-alpha (TNF) sensitivity. The TNF-alpha signaling cascade involves events, like receptor clustering and cleavage of membrane constituent lipid molecules by phospholipases, which are influenced by the physical state of cellular membranes. We discuss the possible involvement of non-bilayer forming lipids in the control of signaling mechanisms leading to TNF cytotoxicity.

Citations

Jun 20, 2000·Antimicrobial Agents and Chemotherapy·M YounsiJ Coulon
Aug 2, 2001·Proceedings of the National Academy of Sciences of the United States of America·P KachrooD F Klessig
Mar 21, 2006·European Journal of Pharmacology·Marianna FantinCsaba Vizler
Jun 9, 2005·Journal of Peptide Science : an Official Publication of the European Peptide Society·Tamás LetohaBotond Penke
Aug 30, 2005·Annals of the New York Academy of Sciences·András TelekesErno Duda
Jul 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·György FejérErno Duda
Oct 5, 2014·Molecular and Cellular Biochemistry·Luka AndrisicAna Cipak Gasparovic
Nov 3, 2001·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·S L HsiehC M Kuo
Jan 24, 2006·International Immunopharmacology·K KisL Kemeny
Jan 23, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·F Scott Heinemann, Juris Ozols
Dec 21, 2004·International Journal of Cancer. Journal International Du Cancer·Stacy MoorePeter S Nelson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.