Highly loaded behavior of kinesins increases the robustness of transport under high resisting loads

PLoS Computational Biology
Woochul Nam, Bogdan I Epureanu

Abstract

Kinesins are nano-sized biological motors which walk by repeating a mechanochemical cycle. A single kinesin molecule is able to transport its cargo about 1 μm in the absence of external loads. However, kinesins perform much longer range transport in cells by working collectively. This long range of transport by a team of kinesins is surprising because the motion of the cargo in cells can be hindered by other particles. To reveal how the kinesins are able to accomplish their tasks of transport in harsh intracellular circumstances, stochastic studies on the kinesin motion are performed by considering the binding and unbinding of kinesins to microtubules and their dependence on the force acting on kinesin molecules. The unbinding probabilities corresponding to each mechanochemical state of kinesin are modeled. The statistical characterization of the instants and locations of binding are captured by computing the probability of unbound kinesin being at given locations. It is predicted that a group of kinesins has a more efficient transport than a single kinesin from the perspective of velocity and run length. Particularly, when large loads are applied, the leading kinesin remains bound to the microtubule for long time which increas...Continue Reading

References

Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D D Hackney
Feb 23, 1995·Nature·S P GilbertK A Johnson
Jun 3, 1994·Cell·K Svoboda, S M Block
Apr 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·H HiguchiT Yanagida
Jul 24, 1997·Nature·M J Schnitzer, S M Block
Jul 24, 1997·Nature·W HuaJ Gelles
Jan 28, 1999·The Journal of Biological Chemistry·D L CoyJ Howard
Jul 17, 1999·Nature·K VisscherS M Block
Mar 29, 2000·Biophysical Journal·S YamadaS C Kuo
Sep 14, 2000·Proceedings of the National Academy of Sciences of the United States of America·C GergelyJ Hemmerlé
Oct 12, 2000·Nature Cell Biology·M J SchnitzerS M Block
Nov 22, 2000·The Journal of Cell Biology·K S ThornR D Vale
Apr 3, 2001·Nature Cell Biology·M NishiyamaH Higuchi
Apr 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Sotaro UemuraShin'ichi Ishiwata
Oct 3, 2002·Nature Cell Biology·Masayoshi NishiyamaToshio Yanagida
Mar 18, 2003·Nature Structural Biology·Sotaro Uemura, Shin'ichi Ishiwata
Apr 9, 2004·European Biophysics Journal : EBJ·D B HillG Holzwarth
Dec 1, 2004·Proceedings of the National Academy of Sciences of the United States of America·Cécile LeducJacques Prost
May 20, 2005·Nature·N J Carter, R A Cross
Aug 9, 2005·Trends in Cell Biology·Harukata MikiNobutaka Hirokawa
Nov 17, 2005·Proceedings of the National Academy of Sciences of the United States of America·Stefan Klumpp, Reinhard Lipowsky
Sep 18, 2007·Biophysical Journal·Janina BeegReinhard Lipowsky
Mar 4, 2008·Biophysical Journal·Otger CampàsJacques Prost
Apr 16, 2009·Nano Letters·Irene DujovneCees Dekker
Apr 28, 2009·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Adam G HendricksEdgar Meyhöfer
Nov 13, 2009·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Ziqing Wang, Ming Li
Feb 18, 2010·Proceedings of the National Academy of Sciences of the United States of America·Charles V Sindelar, Kenneth H Downing
Nov 30, 2005·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Comert KuralPaul R Selvin
Jul 31, 2012·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Woochul Nam, Bogdan I Epureanu
Dec 12, 2012·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Woochul NamBogdan I Epurenau
Mar 5, 2014·The Journal of Chemical Physics·Xiaojun Yao, Yujun Zheng

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Citations

Aug 8, 2015·FEBS Letters·María Cecilia De RossiValeria Levi
Apr 14, 2017·Biophysical Journal·Jingchen Li, Hongyuan Jiang
May 31, 2019·Physical Review Letters·Hamid Khataee, Jonathon Howard
Jun 25, 2020·Physical Review. E·Kejie ChenBogdan I Epureanu
Jul 22, 2020·Physical Review. E·A B Fernández CasafuzL Bruno
Jan 2, 2018·The Journal of Physical Chemistry. B·Aidan I Brown, David A Sivak

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