Highly Ordered and Field-Free 3D DNA Nanostructure: The Next Generation of DNA Nanomachine for Rapid Single-Step Sensing

Journal of the American Chemical Society
Pu ZhangYaqin Chai

Abstract

Herein, by directly using Watson-Crick base pairing, a highly ordered and field-free three-dimensional (3D) DNA nanostructure is self-assembled by azobenzene (azo)-functionalized DNA nippers in a few minutes, which was applied as a 3D DNA nanomachine with an improved movement efficiency compared to traditional Au-based 3D nanomachines due to the organized and high local concentration of nippers on homogeneous DNA nanostructure. Once microRNA (miRNA) interacts with the 3D nanomachine, the nippers "open" to hybridize with the miRNA. Impressively, photoisomerization of the azo group induces dehybridization/hybridization of the nippers and miRNA under irradiation at different wavelengths, which easily solves one main technical challenge of DNA nanotechnology and biosensing: reversible locomotion in one step within 10 min. As a proof of concept, the described 3D machine is successfully applied in the rapid single-step detection of a biomarker, which gives impetus to the design of new generations of mechanical devices beyond the traditional ones with ultimate applications in sensing analysis and diagnostic technologies.

References

Sep 2, 2004·Journal of the American Chemical Society·Jong-Shik Shin, Niles A Pierce
Nov 26, 2005·Science·Kyle Kai-How FarhDavid P Bartel
Feb 24, 2011·Journal of the American Chemical Society·Martin McCullaghGeorge C Schatz
Jan 11, 2012·Journal of the American Chemical Society·Chao ZhouDongsheng Liu
Feb 3, 2012·Angewandte Chemie·Mingxu YouWeihong Tan
Jan 15, 2013·Journal of the American Chemical Society·Tao Li, Michael Famulok
Jul 4, 2013·Nature Communications·Minghui LiuHao Yan
Dec 10, 2013·Nature Nanotechnology·Tae-Gon ChaJong Hyun Choi
Dec 17, 2014·Current Opinion in Biotechnology·Jing PanJong Hyun Choi
Feb 3, 2015·Nano Letters·Lianzhe HuItamar Willner
Jul 8, 2015·Journal of the American Chemical Society·Tae-Gon ChaJong Hyun Choi
Oct 13, 2015·Angewandte Chemie·Hongquan ZhangX Chris Le
Mar 29, 2016·Journal of the American Chemical Society·Chun-Hua LuItamar Willner
Dec 10, 2016·Journal of the American Chemical Society·Yujeong LeeScott K Silverman
Dec 14, 2016·Journal of the American Chemical Society·Hye Ran KohSua Myong
Jan 13, 2017·Angewandte Chemie·Xiangmeng QuChunhai Fan
Jan 24, 2017·Nature·Ryan J GoldenJoshua T Mendell
Feb 16, 2017·Chemistry : a European Journal·Yangyang YangMasayuki Endo
Mar 14, 2017·Journal of the American Chemical Society·Antoine GoujonNicolas Giuseppone
Jun 29, 2017·Nature·XiaoZhi Lim
Jul 21, 2017·Journal of the American Chemical Society·Guillaume De BoJohn W Ward
Aug 18, 2017·Journal of the American Chemical Society·Edmund C M TseJacqueline K Barton

❮ Previous
Next ❯

Citations

Dec 13, 2018·Chemical Communications : Chem Comm·Yanyan YuHuaping Peng
Mar 8, 2019·Advanced Healthcare Materials·Divita Mathur, Igor L Medintz
Jan 31, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Dong ZhangJie Zheng
Feb 19, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Rashaad A HusainZong-Hong Lin
Apr 18, 2020·Advanced Materials·Yingxu ShangBaoquan Ding
Feb 16, 2020·Chemistry : a European Journal·Peng YangWen-Bin Liang
Aug 22, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ying ZhangMingying Yang
Jun 20, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Yan ZhangGuo-Yu Yang
Aug 14, 2019·Chemical Society Reviews·Wenjing WangJun-Jie Zhu
Feb 29, 2020·Chemical Science·Xiao-Long ZhangRuo Yuan
Oct 13, 2020·Nucleic Acids Research·Chanjuan LiuBin Wang
Feb 16, 2021·Chemical Communications : Chem Comm·Xin LiuPeng Miao
Jun 5, 2021·Advanced Healthcare Materials·Luyao ShenYonggang Ke
Jul 2, 2021·Biosensors & Bioelectronics·Zhenqiang NingYanfei Shen
Jul 15, 2021·Advanced Science·Shasha LuXiurong Yang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.