Highly ordered supra-molecular organization of the mycobacterial lipoarabinomannans in solution. Evidence of a relationship between supra-molecular organization and biological activity

Journal of Molecular Biology
M RivièreGermain Puzo

Abstract

The complex mycobacterial mannosylated lipoarabinomannans (ManLAMs) are currently considered to be the major virulence factors of the pathogenic Mycobacterium tuberculosis. The recognition and the interaction of ManLAMs with immune system receptors have been shown to promote M.tuberculosis phagocytosis but also to down-regulate the bactericidal immune response of the host in favor of the survival of the pathogenic bacilli. To date these original biological activities were mainly associated to the presence of mannose residues capping the non-reducing ends of the ramified polysaccharide moiety of these complex lipoglycans. However, we demonstrated recently that the molecular recognition of ManLAM terminal mannose units by human pulmonary surfactant protein A (hSP-A) carbohydrate recognition domains depends on the presence of the lipid moiety of the ManLAMs as proposed by Sidobre et al. in 2002. Thus, we investigated the putative role of the ManLAM aglycon moiety. The data presented here, indicate that the hydrophobic aglycon part of ManLAM is associated to a characteristic concentration-dependent supra-molecular organization of these complex molecules. Furthermore, we observed that the deacylated ManLAMs or the lipid-free mannosy...Continue Reading

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Citations

May 15, 2013·Proceedings of the National Academy of Sciences of the United States of America·Emilyne BlattesGermain Puzo
Sep 3, 2010·Nihon saikingaku zasshi. Japanese journal of bacteriology·Takashi MatsubaYasuhiko Suzuki
Sep 19, 2008·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Szczepan JózefowskiKatarzyna Kwiatkowska
Dec 14, 2007·The Journal of Law, Medicine & Ethics : a Journal of the American Society of Law, Medicine & Ethics·Allyn L Taylor
Jan 8, 2013·The Journal of Law, Medicine & Ethics : a Journal of the American Society of Law, Medicine & Ethics·Lisa S Parker, Valerie B Satkoske
Apr 16, 2013·The Journal of Law, Medicine & Ethics : a Journal of the American Society of Law, Medicine & Ethics·I Glenn Cohen
Mar 28, 2006·The American Journal of Pathology·Robert L HunterJeffrey K Actor
Jun 13, 2008·The Journal of Law, Medicine & Ethics : a Journal of the American Society of Law, Medicine & Ethics·Susan M WolfBenjamin S Wilfond
Apr 12, 2011·Biochimica Et Biophysica Acta·Yasu S MoritaTaroh Kinoshita
Jan 30, 2015·Frontiers in Cellular and Infection Microbiology·Isabelle VergneJérôme Nigou
Dec 30, 2014·Frontiers in Cellular and Infection Microbiology·Ainhoa ArbuesCatherine Astarie-Dequeker
Jul 27, 2017·Chemical Communications : Chem Comm·Anne-Marie Caminade
Oct 28, 2005·Journal of Molecular Recognition : JMR·Rebecca L Rich, David G Myszka
Dec 25, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jessica S HookJessica G Moreland
Mar 8, 2011·Natural Product Reports·Ilona ChlubnováVincent Ferrières
Apr 6, 2017·Frontiers in Cellular and Infection Microbiology·Marta Alonso-HearnRamon A Juste
Dec 7, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Sylvia SchmidPeter Bäuerle
Feb 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marie-Pierre PuissegurFrédéric Altare
Nov 8, 2008·The Journal of Organic Chemistry·Bert Fraser-ReidChangalvala V S Ramamurty
Mar 9, 2011·The Journal of Organic Chemistry·Changalvala V S RamamurtyBert Fraser-Reid
Aug 9, 2012·Bioconjugate Chemistry·Laure DehuyserAlain Wagner

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