Highly Oxygenated Constituents from a Marine Alga-Derived Fungus Aspergillus giganteus NTU967.

Marine Drugs
Jih-Jung ChenTzong-Huei Lee

Abstract

Agar-based disc diffusion antimicrobial assay has shown that the ethyl acetate extract of the fermented broth of Aspergillus giganteus NTU967 isolated from Ulva lactuca exhibited significant antimicrobial activity in our preliminary screening of bioactive fungal strains. Therefore, column chromatography of the active principles from liquid- and solid-state fermented products of the fungal strain was carried out, and which had led to isolation of eleven compounds. Their structures were determined by spectral analysis to be seven new highly oxygenated polyketides, namely aspergilsmins A-G (1-7), along with previously reported patulin, deoxytryptoquivaline, tryptoquivaline and quinadoline B. Among these, aspergilsmin C (3) and patulin displayed promising anticancer activities against human hepatocellular carcinoma SK-Hep-1 cells and prostate cancer PC-3 cells with IC50 values between 2.7-7.3 μM. Furthermore, aspergilsmin C (3) and patulin exhibited significant anti-angiogenic functions by impeding cell growth and tube formation of human endothelial progenitor cells without any cytotoxicity.

References

Jan 21, 1977·The Journal of Organic Chemistry·G BüchiJ M Townsend
Jan 14, 2011·Natural Product Reports·Mostafa E Rateb, Rainer Ebel
Jun 5, 2015·Marine Drugs·Lijian XuQinggui Wang
Dec 16, 2016·Journal of Natural Products·Ming-Shian LeeTzong-Huei Lee
Nov 9, 2018·Journal of Natural Products·Thi Phuong Thuy HoangOlivier Grovel
Jan 17, 2019·Journal of Food and Drug Analysis·Ruchi Singh Thakur, Bharti Ahirwar
Oct 9, 2019·Journal of Food and Drug Analysis·Ming-Shian LeeTzong-Huei Lee

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Citations

Jun 3, 2021·Journal of Fungi·Efaq NomanWesam Hussain Abdulaal
Jun 30, 2021·Journal of Natural Products·Meng-Hsuan HsiehTzong-Huei Lee
Dec 21, 2021·Frontiers in Pharmacology·Rajeev K SinglaBairong Shen

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Datasets Mentioned

BETA
NTU967

Methods Mentioned

BETA
NMR
column chromatography
Assay
enzyme-linked immunosorbent assay

Software Mentioned

BLAST
MacBiophotonics Image J

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