Highly proliferative intratumoral fibroblasts and a high proliferative microvessel index are significant predictors of tumor metastasis in T3 ulcerative-type colorectal cancer

Human Pathology
Takahiro HasebeAtsushi Ochiai

Abstract

Fibroblast and endothelial cell mitotic figures are seen in some areas of colorectal cancers, and the purpose of this study was to investigate whether the proliferative activity of fibroblasts and endothelial cells plays an important role in tumor progression of T3 ulcerative-type colorectal cancer. The tumor area of 157 colorectal cancers was divided into marginal elevated area and central depressed area (CDA), and at half the depth of the depression the CDA was in turn divided into CDA upper area (CDAU) and CDA lower area (CDAL). The proliferative activity of the tumor cells, fibroblasts, and endothelial cells was assessed immunohistochemically by double CD31/MIB-1 (anti--Ki-67 antigen) staining. The proliferative microvessel index was estimated as the percentage of microvessels lined by MIB-1-positive endothelial cells relative to the total microvessel count. Proliferative activities of tumor cells showed significant associations with those of fibroblasts and the proliferative microvessel indices in all of the corresponding areas. Proliferative activities of fibroblasts also showed significant associations with proliferative microvessel indices in all of the corresponding areas. Colorectal cancers with nodal metastasis showe...Continue Reading

Citations

Nov 4, 2004·Journal of the National Cancer Institute·Matus StudenyMichael Andreeff
May 25, 2011·World Journal of Stem Cells·Dharmendra Kumar MauryaDeryl Troyer
Jul 15, 2009·Breast Cancer Research and Treatment·Lyndsay V RhodesMatthew E Burow
Aug 19, 2010·The American Journal of Surgical Pathology·Motohiro KojimaAtsushi Ochiai
May 16, 2002·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Takahiro HasebeAtsushi Ochiai
Apr 12, 2013·Cell Structure and Function·Xiaohui LongToshimasa Uemura
Jan 18, 2011·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Camino Latorre-RomeroPilar Martin-Duque
May 14, 2003·Virchows Archiv : an International Journal of Pathology·Takahiro HasebeAtsushi Ochiai
Dec 12, 2018·Stem Cell Research & Therapy·Ioannis ChristodoulouVassilis Zoumpourlis
Apr 6, 2005·Pathology, Research and Practice·Shintaro SatohHajime Sugihara

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