Highly Selective, Aptamer-Based, Ultrasensitive Nanogold Colorimetric Smartphone Readout for Detection of Cd(II)

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Lu XuZhixian Gao

Abstract

A highly selective and sensitive method for Cd(II) detection was developed based on aptamer and gold nanoparticles (AuNPs) combined with a colorimetric smartphone readout. The experimental conditions such as reaction time of polydiene dimethyl ammonium chloride (PDDA) and AuNPs, PDDA dose, time of aptamer and PDDA incubation, and aptamer concentration were optimized. Under the optimized conditions, the color and red(R) value of the solution was concentration-dependent on Cd(II). The proposed method exhibited a linear range of 1-400 ng/mL (r2 = 0.9794) with a limit of detection (LOD) of 1 ng/mL. This method had been successfully applied to test and quantify Cd(II) in water and rice samples, and the results were in full agreement with those from the atomic absorption spectrometer. Therefore, low-cost colorimetry demonstrated its potential for practical application in visual or quantitative detection with a smartphone. This approach can be readily applied to other analytes.

References

Dec 21, 2011·Chemical Society Reviews·Ha Na KimJuyoung Yoon
Aug 12, 2014·Biosensors & Bioelectronics·Lin CuiHuangxian Ju
Aug 27, 2014·Analytical Chemistry·Nuria Lopez-RuizLuis F Capitan-Vallvey
Sep 28, 2016·Frontiers in Microbiology·Jun TengBaoguang Li
Jan 1, 2015·Molecular Therapy. Nucleic Acids·Michael Blind, Michael Blank
Aug 15, 2017·Journal of Hazardous Materials·Ruojie ChengGuohua Zhao
Feb 9, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yue ZhangYan Zhao
Mar 24, 2018·Toxicon : Official Journal of the International Society on Toxinology·Wenbo WuShi-Zhong Luo

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Methods Mentioned

BETA
Circular Dichroism
dynamic light-scattering

Software Mentioned

Aptamer
ColorAssist
ColorAssist app

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