Highly selective detection of carbon monoxide in living cells by palladacycle carbonylation-based surface enhanced Raman spectroscopy nanosensors

Analytical Chemistry
Yue CaoYi-Tao Long

Abstract

A novel nanosensor was explored for the highly selective detection of intracellular carbon monoxide (CO) by surface enhanced Raman spectroscopy (SERS) on the basis of palladacycle carbonylation. By assembling new synthesized palladacycles (PC) on the surface of gold nanoparticles (AuNPs), SERS nanosensors (AuNP/PC) were prepared with good SERS activity and reactivity with CO. When the AuNP/PC nanosensors were incubated with a CO-containing system, carbonylation of the PC assembled on AuNPs was initiated, and the corresponding SERS spectra of AuNP/PC changed significantly, which allowed the carbonylation reaction to be directly observed in situ. Upon SERS observation of CO-dependent carbonylation, this SERS nanosensor was used for the detection of CO under physiological conditions. Moreover, benefiting from the specificity of the reaction coupled with the fingerprinting feature of SERS, the developed nanosensor demonstrated high selectivity over other biologically relevant species. In vivo studies further indicated that CO in normal human liver cells and HeLa cells at concentrations as low as 0.5 μM were successfully detected with the proposed SERS strategy, demonstrating its great promise for the analytical requirements in stud...Continue Reading

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Nov 2, 2016·Analytical Chemistry·Weiyong FengGuoqiang Feng
Mar 24, 2018·Chemical Society Reviews·Xiaolin HuangXiaoyuan Chen
Jul 30, 2016·Chemical Communications : Chem Comm·Xiaoxiao LiXiliang Luo
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Nov 10, 2018·Nano Reviews & Experiments·Rouhallah RavanshadBijan Zare
Apr 8, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yi HeYaqin Chai
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Jan 13, 2021·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Juhyun YeoYoonsoo Pang
Nov 29, 2017·Journal of the American Chemical Society·Cristina de la TorreFélix Sancenón
Sep 4, 2019·ACS Nano·Judith LangerLuis M Liz-Marzán
Mar 26, 2019·ACS Applied Materials & Interfaces·Yil-Hwan YouMichael J McShane

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