Highly sensitive amperometric Pt-Nafion gas phase nitric oxide sensor: Performance and application in characterizing nitric oxide-releasing biomaterials

Analytica Chimica Acta
Zheng ZhengMark E Meyerhoff

Abstract

A highly sensitive amperometric gas-phase nitric oxide (NO) sensor based on a Pt working electrode chemically deposited on a Nafion film is described. The Pt electrode is chemically deposited on a Nafion 117 membrane by impregnating the film with Pt(NH3)4(2+) ions, which are then exposed to NaBH4 to precipitate conductive Pt metal. The sensor was characterized with a mass-flow controlled 1 ppm NO standard gas and has an electrochemical surface area of 34 ± 9 cm(2), low limits of detection (4.3 ± 1.1 ppb) and a fast response time (<5s) toward changes in gas phase NO levels. Good correlation was found for measurements with the new amperometric Pt-Nafion sensor vs. chemiluminescence results for detecting the rates of NO release from Carbosil2080A polymer films doped with S-nitroso-N-acetylpenicillamine (R = 0.999, m = 0.999, n = 6) and for electrochemical reduction of nitrite to NO (R = 0.999, m = 0.938, n = 3) mediated by a copper(II)-tri(2-pyridylmethyl)amine complex.

References

Jan 1, 1992·Neuron·D S Bredt, S H Snyder
Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M W RadomskiS Moncada
Feb 11, 1991·Current Opinion in Immunology·C F Nathan, J B Hibbs
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·L J IgnarroG Chaudhuri
Jan 1, 1994·Progress in Neurobiology·S R Vincent
Dec 30, 1993·The New England Journal of Medicine·S Moncada, A Higgs
Feb 11, 1993·The New England Journal of Medicine·R RossaintW M Zapol
Jul 15, 1993·The New England Journal of Medicine·M MonchiA T Dinh-Xuan
Feb 27, 1997·The New England Journal of Medicine·UNKNOWN Neonatal Inhaled Nitric Oxide Study Group
Jul 9, 1998·American Journal of Respiratory and Critical Care Medicine·M YamayaH Sasaki
Aug 12, 1999·Cellular and Molecular Life Sciences : CMLS·J F ArnalJ Rami
Aug 6, 2000·Free Radical Biology & Medicine·N Hogg
Nov 13, 2001·Allergy·M JorissenT Willems
Apr 11, 2002·Chemical Reviews·Peng George WangAdam J Janczuk
Sep 11, 2007·American Journal of Otolaryngology·Mohsen NaraghiAhmadReza Dehpour

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