Highly sensitive analysis of multiple pesticides in foods combining solid-phase microextraction, capillary electrophoresis-mass spectrometry, and chemometrics

Electrophoresis
Javier Hernández-BorgesAlejandro Cifuentes

Abstract

A highly sensitive procedure to detect multiple pesticides at trace levels in foods is presented. Initially a comparative study between capillary electrophoresis (CE)-UV and CE-mass spectrometry (MS) is carried out analyzing five pesticides not studied up to now (pyrimethanil, pyrifenox, cyprodinil, cyromazine, and pirimicarb). The comparison between CE-UV and CE-MS is established in terms of separation efficiency, speed of analysis, reproducibility, and sensitivity. A good separation of these compounds is achieved by both techniques using a volatile aqueous buffer containing 0.3 M ammonium acetate/acetic acid at pH 4. Time analysis reproducibility is studied for the same day (n = 5) and three different days (n = 15), showing no significant differences between CE-UV and CE-MS. The study on peak areas reproducibility shows a slightly worse reproducibility for CE-MS compared with CE-UV. The best limit of detection (LOD) that can be achieved for these pesticides using CE-UV was 0.6 microg/mL. CE-MS provides LODs one order of magnitude better than CE-UV. Chemometrics are used to optimize the multiple parameters that play a role in solid-phase microextraction (SPME) and CE-MS analysis (e.g., extraction and desorption times, nebulize...Continue Reading

Citations

Jul 21, 2007·Analytical and Bioanalytical Chemistry·Yolanda Picó, Cornelia Kozmutza
Jan 27, 2005·Journal of Mass Spectrometry : JMS
Mar 12, 2005·Electrophoresis·Carolina SimóAlejandro Cifuentes
Nov 14, 2006·Journal of Chromatography. a·Javier Hernández-BorgesAlejandro Cifuentes
Oct 28, 2005·Electrophoresis·Jens OhnesorgeHermann Wätzig
Oct 12, 2005·Electrophoresis·Javier Hernández-BorgesAlejandro Cifuentes
Jul 15, 2005·Journal of Separation Science·Javier Hernández-BorgesAlejandro Cifuentes
Apr 21, 2009·Electrophoresis·Virginia Rodríguez Robledo, William Franklin Smyth
Jun 12, 2009·Electrophoresis·Christian W Klampfl
Jan 22, 2009·Electrophoresis·Pavla PantůckováLudmila Krivánková
Mar 23, 2007·Electrophoresis·Bricio SantosMiguel Valcárcel
Apr 29, 2006·Electrophoresis·Carolina SimóAlejandro Cifuentes
Apr 11, 2009·Electrophoresis·Lidia M Ravelo-PérezMiguel Angel Rodríguez-Delgado
Oct 25, 2007·Electrophoresis·Lidia M Ravelo-PérezMiguel A Rodríguez-Delgado
May 4, 2007·Electrophoresis·Lidia M Ravelo-PérezMiguel A Rodríguez-Delgado
Oct 30, 2008·Electrophoresis·Encarnación Rodríguez-GonzaloRita Carabias-Martínez
Feb 23, 2007·Journal of Separation Science·Lidia María Ravelo-PérezMiguel Angel Rodríguez-Delgado
Jan 15, 2014·Journal of Separation Science·María Machín-SánchezMaría Candelaria Gil-Rodríguez
Jul 2, 2010·Electrophoresis·Encarnación Rodríguez-GonzaloRita Carabias-Martínez
Jul 11, 2006·Journal of Chromatography. a·Chanbasha BasheerHian Kee Lee
Jul 11, 2006·Journal of Chromatography. a·Carlos Molina-MayoMiguel Angel Rodríguez-Delgado
Nov 30, 2005·Electrophoresis·Ewa Dabek-Zlotorzynska, Valbona Celo
Nov 18, 2018·Journal of Separation Science·Dapeng LiangHuwei Liu
Mar 19, 2005·Electrophoresis·Philippe Schmitt-Kopplin, Matthias Englmann
Jul 15, 2005·Journal of Separation Science·Ana Juan-GarcíaYolanda Picó

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