Highly Sensitive and Reusable Membraneless Field-Effect Transistor (FET)-Type Tungsten Diselenide (WSe2 ) Biosensors

ACS Applied Materials & Interfaces
Hae Won LeeJin-Hong Park

Abstract

In recent years when the demand for high-performance biosensors has been aroused, a field-effect transistor (FET)-type biosensor (BioFET) has attracted great interest because of its high sensitivity, label-free detection, fast detection speed, and miniaturization. However, the insulating membrane in the conventional BioFET, which is essential in preventing the surface dangling bonds of typical semiconductors from nonspecific bindings, has limited the sensitivity of biosensors. Here, we present a highly sensitive and reusable membraneless BioFET based on a defect-free van der Waals material, tungsten diselenide (WSe2). We intentionally generated a few surface defects that serve as extra binding sites for the bioreceptor immobilization through weak oxygen plasma treatment, consequently magnifying the sensitivity values to 2.87 × 105 A/A for 10 mM glucose. The WSe2 BioFET also maintained its high sensitivity even after several cycles of rinsing and glucose application were repeated.

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Citations

Feb 1, 2020·Biomicrofluidics·Kevin D DorfmanC Daniel Frisbie
Nov 9, 2020·Biomaterials·Si MengS Meng
Apr 20, 2021·Biomedical Engineering Letters·Daeun Sung, Jahyun Koo
Jun 3, 2021·Sensors·Reem KhanSilvana Andreescu
Jun 22, 2021·Nanoscale·Linling XuAli Zavabeti

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