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Highly sensitive fluorescence detection of target DNA by coupling exonuclease-assisted cascade target recycling and DNAzyme amplification

Biosensors & Bioelectronics

Jul 27, 2014

Shufeng LiuFeng Li

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PubMed

Abstract

Because of the intrinsic importance of nucleic acid as bio-targets, the simple and sensitive detection of nucleic acid is very essential for biological studies and medical diagnostics. Herein, a simple, isothermal and highly sensitive fluorescence detection of target DNA was developed w...read more

Mentioned in this Paper

Aptamers, Nucleotide
Protrusion
Ribonucleotides
DNA, Catalytic
Polymerase
DNA Probes
Biosensors
Nucleic Acid Hybridization Procedure
Endonuclease
Analog
Paper Details
References
  • References1
  • Citations17
1
  • References1
  • Citations17
12

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Highly sensitive fluorescence detection of target DNA by coupling exonuclease-assisted cascade target recycling and DNAzyme amplification

Biosensors & Bioelectronics

Jul 27, 2014

Shufeng LiuFeng Li

PMID: 25063920

DOI: 10.1016/j.bios.2014.07.023

Abstract

Because of the intrinsic importance of nucleic acid as bio-targets, the simple and sensitive detection of nucleic acid is very essential for biological studies and medical diagnostics. Herein, a simple, isothermal and highly sensitive fluorescence detection of target DNA was developed w...read more

Mentioned in this Paper

Aptamers, Nucleotide
Protrusion
Ribonucleotides
DNA, Catalytic
Polymerase
DNA Probes
Biosensors
Nucleic Acid Hybridization Procedure
Endonuclease
Analog

Feeds With Similar Papers

Biosensors for Cancer Detection

Biosensors are devices that are designed to detect a specific biological analyte by essentially converting a biological entity (ie, protein, DNA, RNA) into an electrical signal that can be detected and analyzed. The use of biosensors in cancer detection and monitoring holds vast potential. Biosensors can be designed to detect emerging cancer biomarkers and to determine drug effectiveness at various target sites. Biosensor technology has the potential to provide fast and accurate detection, reliable imaging of cancer cells, and monitoring of angiogenesis and cancer metastasis, and the ability to determine the effectiveness of anticancer chemotherapy agents.

Ribozymes

Ribozymes are catalytic enzymes that are made entirely of ribonucleic acid. These enzymes cleave the complementary mRNA sequence and are being studied as potential therapies for some dominantly inherited diseases. Discover the latest research on ribozymes here.

Related Papers

Paper Details
References
  • References1
  • Citations17
1
  • References1
  • Citations17
12

Download from

Publisher
PubMed
/papers/highly-sensitive-fluorescence-detection-of-target/25063920