Highly Sensitive Ratiometric Fluorescent Detection of Indium(III) Using Fluorescent Probe Based on Phosphoserine as a Receptor

Analytical Chemistry
Pramod Kumar MehtaKeun-Hyeung Lee

Abstract

Indium is one of the most widely used scarce metals for manufacturing various electronic devices including notebooks, mobile phones, and PC monitors. Recent studies revealed that indium and its compound could cause several toxicities to human beings and animals. However, there is no report about ratiometric fluorescent detection of In(III) in aqueous solutions. We synthesized a fluorescent probe (1) for In(III) based on a phosphoserine as a receptor with a pyrene fluorophore using solid phase synthesis. 1 showed highly sensitive ratiometric response to In(III) in purely aqueous solutions by increasing excimer emission intensity at 476 nm with a concomitant decrease in monomer emission intensity at 395 nm. 1 showed sensitive ratiometric responses to In(III) over a wide range of pH (2 < pH < 8) and exhibited a highly selective ratiometric response to In(III) among 18 tested metal including Al(III) and Ga(III). Job's plot analysis indicated that 1 preferred to form a 2:1 complex with In(III) and the binding affinity for In(III) was measured to be 2.3 × 1012 M-2 ( R2 = 0.989). 1 showed linear ratiometric responses to nanomolar concentrations (0-750 nM) of In(III) and the detection limit was calculated to be 64 nM ( R2 = 0.992) in a...Continue Reading

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