Highly significant linkage to chromosome 3q13.31 for rhinitis and related allergic diseases

Journal of Medical Genetics
C Brasch-AndersenT A Kruse

Abstract

Allergic diseases such as asthma and rhinitis have closely related phenotypes and often occur with atopy. They show strong familial and intra-individual clustering, suggesting overlapping disease aetiology. Various loci and candidate genes have been suggested to underlie allergy. Many or all are still inconclusive. Following genome-wide scans on multiple phenotypes, we previously suggested that chromosome 3q13.12-q21.2 harbours an allergy locus. To identify candidate loci in the Danish population, two additional independent sets of sib-pair families were fine-scale mapped in candidate regions showing maximum likelihood scores (MLS) > or =1.5 in the genome-wide scans. Twenty eight microsatellite markers in a denser map on chromosome 3q were analysed in 236 allergy sib-pair families including 125 sib pairs with rhinitis. We report significant evidence for linkage to chromosome 3q13.31 for rhinitis (MLS 5.55, identity by descent (IBD) 63.9%) and atopy (increased specific immunoglobulin E) (MLS 3.71, IBD 61.7%). We obtained an MLS of 5.1 (IBD 67.3%) at 3q13.31 when sib pairs with both rhinitis and atopy were analysed. This study reports the first statistically significant evidence for a genetic susceptibility locus for rhinitis and...Continue Reading

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Citations

Mar 16, 2012·European Journal of Human Genetics : EJHG·Lisbeth Venø KruseAnders Dupont Børglum
May 22, 2007·Journal of Medical Genetics·Thomas Juhl CorydonAnders Dupont Børglum
Sep 12, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M HisberguesA Jacquet
Jul 4, 2006·The Journal of Allergy and Clinical Immunology·Simon P HoganMarc E Rothenberg
Nov 28, 2013·American Journal of Rhinology & Allergy·Jonathan A Bernstein
Apr 12, 2007·American Journal of Rhinology·Alexander D KaratzanisGeorge A Velegrakis
Oct 22, 2011·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Yoo Jeong HanJoe G N Garcia
May 24, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tianju LiuSem H Phan

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