Highly specific dual enzyme-mediated payload release from peptide-coated silica particles

Journal of the American Chemical Society
Paul D Thornton, Andreas Heise

Abstract

Stimuli-responsive gate mechanisms offer potential for the controlled passage of payload molecules from a porous carrier vehicle on-demand. We describe a method for the enzyme-mediated release of macromolecular guest molecules from inorganic silica particles coated with a bioactive peptide shell, synthesized precisely by Fmoc chemistry. Specific enzymatic hydrolysis of the peptide shell removes the bulky peptide-terminated Fmoc groups, permitting the selective release of previously entrapped guest molecules.

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Citations

Feb 7, 2012·Journal of the American Chemical Society·Meng-Hua XiongJun Wang
Nov 25, 2011·ACS Nano·Jun GeRichard N Zare
Jan 25, 2011·Chemical Communications : Chem Comm·Paul D Thornton, Andreas Heise
Sep 9, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Yufang ZhuNobutaka Hanagata
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Aug 1, 2014·Small·Núria MasRamón Martínez-Máñez
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May 2, 2015·Nanoscale·Devleena SamantaRichard N Zare
Dec 17, 2014·Chemical Communications : Chem Comm·Mthulisi KhuphePaul D Thornton
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