Highly Stable 177Lu-Organic Framework as a Potential Agent for Treatment of Metastatic Bone

IEEE Transactions on Nanobioscience
Nafiseh SalekMohammad Ghannadi-Maragheh

Abstract

In this paper, the metal organic framework (MOF) concept is contributed to rearrange the bone-seeking agent composed of carrier-free lutetium-177 (Lu-177), 1, 4, 7, 10-tetraazacyclododecane-1, 4, 7, 10-tetraaminomethylenephosphonate (DOTMP) and cupper (II) (Cu (II)) for preparation of a potential agent for treatment of bone metastases. The product was characterized (infra-red spectroscopy, IR, and X-ray diffraction analysis) and quality-controlled (radio-thin layer chromatography, (RTLC)). The stability and in vitro hydroxyapatite binding was checked up to 1.5 month at 37 °C in human serum. Radio-MOF crystals and radio-MOF particles that were obtained by varying the synthesizing conditions (including pH and temperature) showed similar IR patterns and similar elemental analysis results. The final product was synthesized at pH = 8, stirring at room temperature (yield >99%, RTLC, particle size: 90 ± 20 nm). Biodistribution study experiments showed interesting bone-seeking (%ID/g: 8.5%) affinity of the prepared formula with no significant liver or lung uptake. Also high accumulation of radio-complex in bone tissue was estimated by the modeling of the radiation dose delivery using radiation dose assessment resource software. This no...Continue Reading

References

Jan 1, 1990·International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology·C L de LignyH A Vink
Jan 1, 1993·European Journal of Nuclear Medicine·V J Lewington
Sep 1, 1996·The Journal of the American Dental Association·J M Firestone
Aug 2, 2002·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Tapas DasM R A Pillai
Aug 27, 2003·Health Physics·Michael G Stabin, Jeffry A Siegel
Jun 17, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sten NilssonOyvind S Bruland
Oct 26, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Robert E Coleman
Sep 7, 2007·Cancer Biotherapy & Radiopharmaceuticals·Orazio SchillaciKathleen R Lamborn
Feb 1, 2011·International Journal of Radiation Oncology, Biology, Physics·Stephen LutzUNKNOWN American Society for Radiation Oncology (ASTRO)
Feb 23, 2011·Bioconjugate Chemistry·Rafael Torres Martin de RosalesPhilip J Blower
Jul 24, 2013·International Journal of Clinical Oncology·Sadamoto ZendaTetsuo Akimoto
Nov 13, 2013·Journal of the American Chemical Society·Arnau Carné-SánchezDaniel Maspoch
Mar 8, 2014·Chemical Society Reviews·Weigang LuHong-Cai Zhou
May 9, 2014·Journal of Biomedical Nanotechnology·Beatriz Ferreira de Carvalho PatricioGilberto Weissmüller
May 17, 2014·Chemical Society Reviews·Zhenjie Zhang, Michael J Zaworotko
Jul 12, 2014·Chemical Society Reviews·Hong-Cai Joe Zhou, Susumu Kitagawa
Jul 15, 2015·Chemical Society Reviews·Patrícia SilvaFilipe A Almeida Paz
Aug 11, 2015·Journal of Advanced Research·Nicholas PavlidisRabab Gaafar
Jun 19, 2016·International Journal of Radiation Oncology, Biology, Physics·Paulien G WesthoffUNKNOWN Dutch Bone Metastasis Study Group

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Citations

Nov 21, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Lijuan ZengGan Tian

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