Highly Stable and Long-Circulating Metal-Organic Frameworks Nanoprobes for Sensitive Tumor Detection In Vivo

Advanced Healthcare Materials
Ruili ZhangZhongliang Wang

Abstract

High stability and extended circulation time in vivo are quite favorable for practical biomedical applications of nanomaterials, because they greatly facilitate the preferential tumor accumulation of nanomaterials, resulting in enhanced signal fidelity for imaging and improved therapeutic effect for treatment. Although many surface modification approaches have been employed to improve the stability and circulating behavior of nanomaterials, it still remains challenging in acquiring stable and long-lasting nanomaterials for in vivo bioimaging and therapy, especially for nanoscale metal-organic frameworks (NMOFs) due to their intrinsic instability in physiological conditions. Herein, a facile, one-step strategy is reported to encapsulate the zirconium (Zr)-based NMOF UiO-66 within 1,2-dioleoyl-sn-glycero-3-phosphate (DOPA) lipid bilayer (DOPA-LB). Contrary to UiO-66 NMOFs functionalized with polyethylene glycol, the obtained UiO-66@DOPA-LB presents significantly enhanced stability and impressive blood circulation time, allowing a higher accumulation of UiO-66@DOPA-LB in the tumor tissue. Benefited from these meritorious features, UiO-66@DOPA-LB labeled with near-infrared dye, IRDye 800CW, can not only achieve highly sensitive ima...Continue Reading

References

Jul 10, 2010·Nature Reviews. Drug Discovery·Robby A Petros, Joseph M DeSimone
Jun 22, 2011·Chemical Reviews·Yuanjing CuiBanglin Chen
Jul 2, 2011·Nanomedicine·Jesse V JokerstSanjiv S Gambhir
Aug 31, 2013·Science·Hiroyasu FurukawaOmar M Yaghi
May 6, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Joseph W Nichols, You Han Bae
May 14, 2014·Journal of the American Chemical Society·William MorrisChad A Mirkin
Mar 17, 2015·Advanced Healthcare Materials·Elena BellidoPatricia Horcajada
Oct 13, 2015·Advanced Drug Delivery Reviews·Jung Soo SukLaura M Ensign
Oct 24, 2015·Angewandte Chemie·Shunzhi WangChad A Mirkin
Mar 25, 2016·Chemical Communications : Chem Comm·Weiqi WangZhigang Xie
May 4, 2016·Advanced Drug Delivery Reviews·Jennifer I HareSimon T Barry
Nov 12, 2016·Nature Reviews. Cancer·Jinjun ShiOmid C Farokhzad
Feb 25, 2017·Advanced Materials·Qihang SunYouqing Shen
Apr 4, 2017·Advanced Materials·Ming-Xue Wu, Ying-Wei Yang
Jul 19, 2017·Journal of the American Chemical Society·Shunzhi WangChad A Mirkin
Sep 20, 2017·ACS Applied Materials & Interfaces·Claudia Orellana-TavraDavid Fairen-Jimenez
Sep 20, 2017·ACS Nano·Mattias BjörnmalmFrank Caruso
Oct 27, 2017·Chemical Society Reviews·Dalong NiJianlin Shi
Oct 28, 2017·Nature Reviews. Materials·Hongmin ChenXiaoyuan Chen
Jun 3, 2016·Bioengineering & Translational Medicine·Aaron C Anselmo, Samir Mitragotri
Mar 15, 2018·Angewandte Chemie·Xizhen LianHong-Cai Zhou
Jun 8, 2018·Advanced Materials·Teresa Simon-YarzaChristian Serre

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.