Highly Stable and Multiemissive Silver Nanoclusters Synthesized in Situ in a DNA Hydrogel and Their Application for Hydroxyl Radical Sensing

ACS Applied Materials & Interfaces
Jing LiLeilei Tian

Abstract

Oligonucleotide-stabilized silver nanoclusters (AgNCs) show promising applications in bioimaging and bio-/chemo-sensing. However, their unsatisfactory photostability limits their practical applications. In this work, fluorescent AgNCs were synthesized in situ in a DNA hydrogel, consisting of cross-linked enzymatically amplified polymeric DNAs with cytosine-rich sequences in the presence of Ag+. The fluorescence property of the resultant AgNCs was optimized by a rational design of the DNA sequences to cover a broad spectrum with comparable green and red emissions. Under the protection of the DNA hydrogel, the AgNCs showed significantly improved photostability in an ambient oxygen environment, as well as low cytotoxicity even at a high concentration. Therefore, these properties show the rolling-circle-amplification-stabilized AgNCs to be a promising possible fluorescent probe for the detection of reactive oxygen/nitrogen species (ROS/RNS) in live cells because red-emitting species are susceptible to oxidation and consequently convert to green-emitting species. Finally, the as-prepared AgNCs were demonstrated to be a sensitive and specific probe for cellular imaging and the monitoring of ROS/RNS levels, which broadens the applicat...Continue Reading

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Citations

Aug 6, 2019·Advanced Materials·Fengyun LiWeiwei Guo
Mar 9, 2020·Topics in Current Chemistry·Jie ChenLihua Wang
Nov 9, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ye TengNaoki Sugimoto
Jul 25, 2020·Nanoscale·Liam YourstonAlexey V Krasnoslobodtsev
Mar 16, 2021·Trends in Biotechnology·Shuzhen YueSai Bi
May 4, 2021·Advanced Healthcare Materials·Anna HerrmannUwe Schedler
Aug 29, 2019·ACS Omega·Cecilia Cerretani, Tom Vosch
Jul 10, 2019·The Journal of Physical Chemistry. B·Joshua A SnyderBern Kohler
Jan 16, 2021·ACS Biomaterials Science & Engineering·Vinod MoryaDhiraj Bhatia
Sep 16, 2021·Chemical Communications : Chem Comm·Junxiao LiuWei Qi

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