Highly stereoselective ruthenium(II)-catalyzed direct C2-syn-alkenylation of indoles with alkynes

Organic Letters
Wei ZhangWei Zeng

Abstract

A carboamide-directed ruthenium-catalyzed C2-hydroindolation of alkynes has been described. This transformation provides a rapid access to free (N-H) C2-syn-alkenylated indole derivatives with the assistance of copper(II) salts, in which the directing group is removed via a one-pot process.

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Citations

Dec 23, 2016·The Journal of Organic Chemistry·Tingjie YouYuanzhi Xia
Sep 19, 2015·Organic & Biomolecular Chemistry·Rajendran Manikandan, Masilamani Jeganmohan
Jun 24, 2017·Chemistry : a European Journal·Marino Petrini
Oct 30, 2015·Angewandte Chemie·Lanting XuDawei Ma
Feb 15, 2020·Chemistry, an Asian Journal·Sunliang CuiYuxin Lin
Apr 23, 2021·Organic & Biomolecular Chemistry·Philipp NathoPhilip J Parsons
May 7, 2021·Organic Letters·Xinwei HuWei Zeng
Aug 14, 2019·The Journal of Organic Chemistry·Woohyeong LeeJung Min Joo

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