Highly water-stable rare ternary Ag-Au-Se nanocomposites as long blood circulation time X-ray computed tomography contrast agents

Nanoscale
Carlos CaroManuel Pernia Leal

Abstract

X-ray computed tomography (CT) is a powerful and widely used medical non-invasive technique that often requires intravenous administration of contrast agents (CAs) to better visualize soft tissues. In this work, we have developed a novel CT contrast agent based on ternary Ag-Au-Se chalcogenide nanoparticles (NP). A facile ligand exchange by using a 3 kDa PEGylated ligand with a dithiol dihydrolipoic acid as an anchor group resulted in highly water-soluble and monodisperse nanoparticles. These PEGylated ternary NPs were tested in vivo in mice, showing slow uptake by the mononuclear phagocyte system, long blood circulation times, low toxicity, and very good X-ray contrast, thus being promising candidates as CT contrast agents for clinical applications.

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Citations

Aug 18, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Li LiGuan-Hai Wang
May 14, 2020·Nanomaterials·Valentin NicaMaria Luisa Garcia-Martin
Dec 23, 2017·ACS Applied Materials & Interfaces·Sisi YangMiao Yu

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