Highs and lows of hyperoxia: physiological, performance, and clinical aspects

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Julien Vincent BrugniauxPhilip N Ainslie

Abstract

Molecular oxygen (O2) is a vital element in human survival and plays a major role in a diverse range of biological and physiological processes. Although normobaric hyperoxia can increase arterial oxygen content ([Formula: see text]), it also causes vasoconstriction and hence reduces O2 delivery in various vascular beds, including the heart, skeletal muscle, and brain. Thus, a seemingly paradoxical situation exists in which the administration of oxygen may place tissues at increased risk of hypoxic stress. Nevertheless, with various degrees of effectiveness, and not without consequences, supplemental oxygen is used clinically in an attempt to correct tissue hypoxia (e.g., brain ischemia, traumatic brain injury, carbon monoxide poisoning, etc.) and chronic hypoxemia (e.g., severe COPD, etc.) and to help with wound healing, necrosis, or reperfusion injuries (e.g., compromised grafts). Hyperoxia has also been used liberally by athletes in a belief that it offers performance-enhancing benefits; such benefits also extend to hypoxemic patients both at rest and during rehabilitation. This review aims to provide a comprehensive overview of the effects of hyperoxia in humans from the "bench to bedside." The first section will focus on th...Continue Reading

References

Mar 1, 1979·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·J W Severinghaus
Feb 1, 1978·Southern Medical Journal·J S ReddingC W Gross
Mar 1, 1977·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·H G WelchN Secher
Jan 1, 1975·Respiration Physiology·M J Miller, S M Tenney
Jul 1, 1975·Journal of Applied Physiology·B EkblomA T Thorstensson
Jan 1, 1992·European Journal of Applied Physiology and Occupational Physiology·J PletJ K Hansen
Aug 1, 1992·Journal of Applied Physiology·M C HoganP D Wagner
Jul 1, 1992·Gastrointestinal Endoscopy·L CrantockR K Roberts
May 1, 1991·The American Journal of Physiology·D R SealsR F Fregosi
Nov 1, 1988·Journal of Applied Physiology·D L BredleS M Cain
Jul 1, 1987·Journal of Applied Physiology·G J Criner, B R Celli
Sep 1, 1986·Journal of Applied Physiology·P A EastonN R Anthonisen
Aug 1, 1985·The American Review of Respiratory Disease·P T ByeR L Pardy
Oct 17, 1973·Pflügers Archiv : European journal of physiology·E Humpeler, H Amor
Sep 17, 1970·The New England Journal of Medicine·J M Van De WaterF D Moore
Mar 1, 1971·The American Review of Respiratory Disease·M N VyasS Grzybowski
May 1, 1971·Journal of Applied Physiology·J M Clark, C J Lambertsen
Jan 1, 1983·Medicine and Science in Sports and Exercise·T E Graham, B A Wilson
Dec 1, 1984·Medicine and Science in Sports and Exercise·W C ByrnesS M Horvath
Oct 1, 1983·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·M C HoganH G Welch
Jun 1, 1995·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·R L Hughson, J M Kowalchuk
Feb 1, 1995·Journal of Applied Physiology·H BeckerC E Sullivan
Mar 1, 1995·Journal of Applied Physiology·L S Howard, P A Robbins
Apr 1, 1995·Medicine and Science in Sports and Exercise·J E PeltonenH K Rusko
Jan 1, 1994·European Journal of Applied Physiology and Occupational Physiology·J H Mateika, J Duffin
Jul 1, 1993·The Journal of International Medical Research·A al-QorainF al-Shedokhi
Dec 1, 1993·Journal of Applied Physiology·D R KnightP D Wagner
Feb 1, 1996·Journal of the American College of Cardiology·W A HaqueL I Sinoway
Jan 1, 1995·European Journal of Applied Physiology and Occupational Physiology·M L Walsh, E W Banister
Sep 1, 1996·The Journal of Thoracic and Cardiovascular Surgery·P O JoachimssonH Rutberg
Jul 1, 1996·Journal of Applied Physiology·D R KnightP D Wagner
Jan 1, 1996·European Journal of Applied Physiology and Occupational Physiology·L L Ploutz-SnyderF C Hagerman
Oct 1, 1996·Journal of Applied Physiology·H F BeckerC E Sullivan
Feb 1, 1997·American Journal of Respiratory and Critical Care Medicine·D E O'DonnellK A Webb
May 1, 1997·Journal of Applied Physiology·P CrawfordL I Sinoway
Oct 20, 1998·Acta Physiologica Scandinavica·H B NielsenN H Secher
Mar 2, 1999·American Journal of Respiratory and Critical Care Medicine·R S RichardsonP D Wagner
Mar 6, 1999·Journal of Applied Physiology·R S RichardsonP D Wagner

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Citations

Aug 6, 2018·Journal of Cellular Physiology·Jennifer L RodgersSiva K Panguluri
Dec 7, 2018·The Journal of Physiology·João D MattosIgor A Fernandes
Jan 18, 2019·Journal of Cellular Physiology·Jennifer L RodgersSiva K Panguluri
Jan 25, 2019·International Journal of Sports Physiology and Performance·David MorawetzWolfgang Schobersberger
Jun 13, 2019·International Journal of Sports Physiology and Performance·David MorawetzWolfgang Schobersberger
Dec 19, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Rafael de Almeida AzevedoJuan M Murias
Sep 11, 2019·Canadian Journal of Physiology and Pharmacology·Otto F BarakZeljko Dujic
Mar 29, 2019·Critical Care : the Official Journal of the Critical Care Forum·Donat R SpahnRolf Rossaint
Jun 26, 2020·Journal of Applied Physiology·Hayden W HessBlair D Johnson
Jun 27, 2020·Oxidative Medicine and Cellular Longevity·Katelyn Dunigan-RussellTrent E Tipple
Aug 25, 2020·Journal of Intensive Care·Ryo Yamamoto, Jo Yoshizawa
Feb 23, 2020·Frontiers in Neurology·Zhiying ChenRan Meng
Aug 28, 2020·Frontiers in Physiology·Verena TretterKlaus Ulrich Klein
May 1, 2021·International Journal of Environmental Research and Public Health·Thays C SilvaRaphael F de Souza
May 2, 2021·Experimental Physiology·Jay M J R CarrPhilip N Ainslie
May 27, 2021·Antioxidants & Redox Signaling·Amaya Lopez-PascualPedro González-Muniesa
Jun 17, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Hayden W HessBlair D Johnson
Jun 5, 2021·American Journal of Respiratory and Critical Care Medicine·Chad H HochbergRoy G Brower

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