Hijacking of the jasmonate pathway by the mycotoxin fumonisin B1 (FB1) to initiate programmed cell death in Arabidopsis is modulated by RGLG3 and RGLG4

Journal of Experimental Botany
Xu ZhangChengcai An

Abstract

The mycotoxin fumonisin B1 (FB1) is a strong inducer of programmed cell death (PCD) in plants, but its underlying mechanism remains unclear. Here, we describe two ubiquitin ligases, RING DOMAIN LIGASE3 (RGLG3) and RGLG4, which control FB1-triggered PCD by modulating the jasmonate (JA) signalling pathway in Arabidopsis thaliana. RGLG3 and RGLG4 transcription was sensitive to FB1. Arabidopsis FB1 sensitivity was suppressed by loss of function of RGLG3 and RGLG4 and was increased by their overexpression. Thus RGLG3 and RGLG4 have coordinated and positive roles in FB1-elicited PCD. Mutated JA perception by coi1 disrupted the RGLG3- and RGLG4-related response to FB1 and interfered with their roles in cell death. Although FB1 induced JA-responsive defence genes, it repressed growth-related, as well as JA biosynthesis-related, genes. Consistently, FB1 application reduced JA content in wild-type plants. Furthermore, exogenously applied salicylic acid additively suppressed JA signalling with FB1 treatment, suggesting that FB1-induced salicylic acid inhibits the JA pathway during this process. All of these effects were attenuated in rglg3 rglg4 plants. Altogether, these data suggest that the JA pathway is hijacked by the toxin FB1 to eli...Continue Reading

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Citations

May 3, 2016·Plants·Astrid Nagels DurandAlain Goossens
Aug 9, 2016·Plant & Cell Physiology·Astrid Nagels DurandAlain Goossens
Jan 19, 2018·Plant Molecular Biology·Ying-Ge WangWan-Chen Li
Nov 20, 2019·Toxins·Lakshmipriya PerincherryŁukasz Stępień
Nov 17, 2020·Frontiers in Plant Science·Hong-Yun ZengNan Yao
Nov 26, 2020·Journal of Proteomics·Kishor D IngoleSaikat Bhattacharjee
Apr 30, 2021·Chemico-biological Interactions·Nadeem IqbalAttila Ördög

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Methods Mentioned

BETA
transgenic
transfection
protein assay
Confocal microscopy
PCR
ubiquitination

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