HIMH0021 attenuates ethanol-induced liver injury and steatosis in mice

PloS One
Yongjun LeeSun Young Kim

Abstract

Chronic alcohol consumption causes alcohol-induced lipogenesis and promotes hepatic injury by preventing the oxidation of hepatocellular fatty acids through the suppression of the activation of AMP-activated protein kinase (AMPK). HIMH0021, an active flavonoid compound, which is a component of the Acer tegmentosum extract, has been shown to protect against liver damage caused by alcohol consumption. Therefore, in this study, we aimed to determine whether HIMH0021 could regulate alcoholic fatty liver and liver injury in mice. Oral administration of 10 days of Lieber-DeCarli ethanol plus a single binge of 30% ethanol (chronic-plus-binge model) induced steatosis and liver injury and inflammation in mice, which appears similar to the condition observed in human patients with alcohol-related diseases. HIMH0021, which was isolated from the active methanol extract of A. tegmentosum, inhibited alcohol-induced steatosis and attenuated the serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) during hepatocellular alcohol metabolism, both of which promote lipogenesis as well as liver inflammation. Treatment with HIMH0021 conferred protection against lipogenesis and liver injury, inhibited the expression of c...Continue Reading

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Citations

Nov 8, 2018·PloS One·Ashley R DeGroatJonathan M Peterson
May 16, 2018·American Journal of Physiology. Endocrinology and Metabolism·Greta TrogenJonathan M Peterson

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Methods Mentioned

BETA
column chromatography
Protein Assay
PCR
ELISA
NMR

Software Mentioned

GraphPad Prism
ImageJ
GraphPad

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