Hind III genomic polymorphism of the C3b receptor (CR1) in patients with SLE: low erythrocyte CR1 expression is an acquired phenomenon

Immunology and Cell Biology
A KumarL M Srivastava

Abstract

Expression of the human erythrocyte C3b receptor (CR1-CD35) and its Hind III RFLP was studied in a group of 37 patients with SLE, 15 consanguineous relatives of the patients and 48 healthy normal subjects. The CR1 number on erythrocytes was quantitated by ELISA using a mAb to CR1. Serum levels of complement proteins (C3, C4, C3d) and circulating immune complexes (CIC) were estimated simultaneously in controls and relatives. The patients were followed up during the course of the treatment. The CR1/erythrocyte (CR1/E) in patients were found to be significantly low in comparison to controls. The gene frequencies for the alleles H and L (7.4 and 6.9 kb Hind III restriction fragments) in the patients were 0.75 and 0.25, respectively, which did not differ significantly from the controls (0.77 and 0.23 in normal subjects and 0.79 and 0.21 in consanguineous relatives of the patients). However, patients expressed fewer CR1/E within each genotype than their relatives and healthy subjects. CR/E was found to be stable in consecutive samples in controls. In patients, the numbers varied between low and high during the course of the treatment. The variation in the numbers was significantly correlated with C3d and CIC as well as with the sever...Continue Reading

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Citations

Dec 25, 2003·Proceedings of the National Academy of Sciences of the United States of America·Ian A CockburnJ Alexandra Rowe
Jul 2, 2002·American Journal of Respiratory Cell and Molecular Biology·Michele ZorzettoMaurizio Luisetti
Jul 2, 2002·American Journal of Respiratory Cell and Molecular Biology·Michael C IannuzziBenjamin A Rybicki
Feb 15, 1997·The Journal of Clinical Investigation·B P TsaoJ I Rotter
Nov 14, 2008·Molecular Immunology·Rohan Khera, Nibhriti Das
Apr 25, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·P SenbagavalliV D Ramanathan

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