Hindbrain and Spinal Cord Contributions to the Cutaneous Sensory Innervation of the Larval Zebrafish Pectoral Fin

Frontiers in Neuroanatomy
Katharine W HendersonMelina E Hale

Abstract

Vertebrate forelimbs contain arrays of sensory neuron fibers that transmit signals from the skin to the nervous system. We used the genetic toolkit and optical clarity of the larval zebrafish to conduct a live imaging study of the sensory neurons innervating the pectoral fin skin. Sensory neurons in both the hindbrain and the spinal cord innervate the fin, with most cells located in the hindbrain. The hindbrain somas are located in rhombomere seven/eight, laterally and dorsally displaced from the pectoral fin motor pool. The spinal cord somas are located in the most anterior part of the cord, aligned with myomere four. Single cell reconstructions were used to map afferent processes and compare the distributions of processes to soma locations. Reconstructions indicate that this sensory system breaks from the canonical somatotopic organization of sensory systems by lacking a clear organization with reference to fin region. Arborizations from a single cell branch widely over the skin, innervating the axial skin, lateral fin surface, and medial fin surface. The extensive branching over the fin and the surrounding axial surface suggests that these fin sensory neurons report on general conditions of the fin area rather than providing...Continue Reading

References

Apr 1, 1977·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·A Roberts, B P Hayes
Sep 1, 1992·Developmental Dynamics : an Official Publication of the American Association of Anatomists·D W RaibleJ S Eisen
Dec 15, 1990·The Journal of Comparative Neurology·R R BernhardtJ Y Kuwada
Jan 22, 1990·The Journal of Comparative Neurology·M Ronan, R G Northcutt
Jan 1, 1988·Annual Review of Neuroscience·R W Williams, K Herrup
Mar 22, 1985·The Journal of Comparative Neurology·J J Kollros, M L Thiesse
Jun 22, 1985·The Journal of Comparative Neurology·P Z Myers
Feb 20, 1982·The Journal of Comparative Neurology·C B KimmelW K Metcalfe
Mar 15, 1980·The Journal of Comparative Neurology·E R Macagno
Jul 31, 2001·The Journal of Comparative Neurology·M E HaleJ R Fetcho
Apr 5, 2002·The Journal of Comparative Neurology·Min AnPaul D Henion
Feb 1, 1955·The Journal of Comparative Neurology·J J KOLLROS, V M McMURRAY
Dec 31, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Rosario ReyesJudith S Eisen
Nov 9, 2004·The Journal of Experimental Biology·Dean H ThorsenMelina E Hale
Jun 14, 2005·The Journal of Comparative Neurology·Günther K H ZupancFred H Gage
Sep 16, 2005·Journal of Morphology·D H Thorsen, M E Hale
Jul 13, 2007·The Journal of Comparative Neurology·Dean H Thorsen, Melina E Hale
Aug 31, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Giorgio A AscoliMaryam Halavi
May 17, 2008·Development, Growth & Differentiation·Kazuhide Asakawa, Koichi Kawakami
Oct 3, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·David A ProberAlexander F Schier
Jun 19, 2009·PloS One·Leung-Hang MaRobert Baker
Jun 2, 2010·The Journal of Cell Biology·Melissa LinkertJason R Swedlow
Aug 10, 2010·Developmental Biology·Yumie MurataMikiko Tanaka
Aug 13, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Naila Ben FredjMartin P Meyer
Sep 14, 2010·Genesis : the Journal of Genetics and Development·Eugenia OlesnickyKristin Bruk Artinger
Oct 27, 2010·Nature Communications·Leung-Hang MaRobert Baker
May 4, 2011·Genesis : the Journal of Genetics and Development·Taras A Zelenchuk, Juan L Brusés
Aug 26, 2011·The Journal of Experimental Biology·Matthew H GreenMelina E Hale
Dec 23, 2011·Development·Y Albert PanAlexander F Schier
Jun 23, 2012·Proceedings of the National Academy of Sciences of the United States of America·Andrew H Bass, Boris P Chagnaud
Jun 30, 2012·Nature Methods·Johannes SchindelinAlbert Cardona
Aug 7, 2012·Developmental Neurobiology·Ana Marie S PalancaAlvaro Sagasti
Aug 30, 2012·Nature Methods·Caroline A SchneiderKevin W Eliceiri
Dec 12, 2012·Bioinspiration & Biomimetics·Matthew H GreenMelina E Hale
Mar 22, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Philia GauAjay Dhaka
Apr 18, 2013·Nature Communications·Richard WilliamsMelina E Hale
Oct 12, 2013·The Journal of Comparative Neurology·Evdokia MenelaouDavid L McLean
Oct 25, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Adèle FaucherreChris Jopling

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BETA
GM107GL

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BETA
transgenic
transgenics
confocal microscopy

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Fiji
Adobe Illustrator
R
ggplot2
macOS
Mathematica
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