Hindbrain effects of PACAP on gastric motor function in the rat

The American Journal of Physiology
Z K KrowickiP J Hornby

Abstract

Pituitary adenylate cyclase-activating polypeptide (PACAP)-like immunoreactive cell bodies and fibers are visualized in hindbrain nuclei that are involved in the regulation of autonomic function, yet little is known about the gastric and cardiovascular effects of this peptide in the dorsal vagal complex, nucleus raphe obscurus, and nucleus ambiguus. Therefore, multiple-barreled micropipettes were used to inject PACAP-38 (1-100 pmol) into each of these nuclei in alpha-chloralose anesthetized rats, while intragastric pressure, pyloric and greater curvature smooth muscle contractile activity, blood pressure, and heart rate were recorded. For comparison, the effect of L-glutamate (15 nmol) microinjected into the same sites on gastric motor activity was also assessed. L-Glutamate microinjected into each nucleus before PACAP-38 significantly increased intragastric pressure, both in terms of the peak increase and the total area of the response. Microinjections of PACAP-38 (10 and 100 pmol) into each of the nuclei significantly increased peak intragastric pressure, but the total area of the response was only significantly increased by the highest dose (100 pmol) in the case of the dorsal vagal complex and nucleus raphe obscurus. No con...Continue Reading

Citations

Aug 14, 2012·American Journal of Physiology. Heart and Circulatory Physiology·M M J FarnhamP M Pilowsky
Feb 15, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Melissa M J FarnhamPaul M Pilowsky
Jun 12, 2020·World Journal of Gastroenterology : WJG·Dong-Qin ZhaoHai-Ji Sun
Nov 5, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Chun-Yi HungG A Burns

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