Hinderance of apoptosis and phagocytic behaviour induced by Escherichia coli cytotoxic necrotizing factor 1: two related activities in epithelial cells

Biochemical and Biophysical Research Communications
Carla FiorentiniWalter Malorni

Abstract

Several microbial factors are recognized able to modulate apoptosis. In this work, we analyze the activity of a toxin from pathogenic strains of Escherichia coli, the Cytotoxic Necrotizing Factor 1 (CNF1), which influences epithelial cell structure and function. This toxin activates the Rho GTP-binding protein leading to actin filament reorganization, membrane ruffling and multinucleation. Functionally, CNF1 induces a phagocytic activity in non-professional phagocytes. Surprisingly, we found that the increase of phagocytic activity induced by CNF1 corresponds to a decrease of apoptotic cell death. We therefore hypothesize that the two activities together might have a finalistic role in the pathogenesis of bacterial infection.

Citations

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis