Hip and calcaneal bone loss increase with advancing age: longitudinal results from the study of osteoporotic fractures

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
K EnsrudS R Cummings

Abstract

It is uncertain whether or how rapidly elderly women continue to lose bone with advancing age. To determine rates of change in bone mass at the hip and at the calcaneus in elderly women and to compare these rates of change among estrogen users and nonusers, we prospectively measured rates of change in bone mineral density (BMD) at the total hip and its four subregions (mean +/- SD, 3.55 +/- 0.29 years between examinations) and at the calcaneus (mean +/- SD, 5.69 +/- 0.33 years between examinations) in 5689 community-dwelling white women aged 65 years or older at the baseline examination. The rate of decline in total hip BMD steadily increased from 2.5 mg/cm 2/year (95% confidence interval 2.0 to 2.9) in women 67-69 years old to 10.4 mg/cm 2/year in those aged 85 or older (95% confidence interval 8.4 to 12.4). The rate of bone loss also increased with aging at all subregions of the hip and at the calcaneus. The average loss of bone from the total hip is sufficient to increase the risk of hip fracture by 21% per 5 years in women aged 80 years or older. Compared with nonusers, current estrogen users had a 33% lower age-adjusted mean rate of loss at the total hip (2.9 vs 4.3 mg/cm 2/year, p < or = 0.0001) and a 35% lower age-adjust...Continue Reading

References

Sep 1, 1978·American Journal of Epidemiology·R S PaffenbargerR T Hyde
Oct 2, 1976·British Medical Journal·S ChakravartiJ W Studd
Aug 11, 1975·The Journal of Clinical Investigation·D M SmithC C Johnston
Dec 3, 1992·The New England Journal of Medicine·M C ChapuyP J Meunier
Jun 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P SteigerH K Genant
Nov 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C W MarxD B Muchmore
Jul 1, 1992·Annals of Internal Medicine·E G LufkinB L Riggs
Feb 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C CooperL J Melton
May 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M T HannanJ J Anderson
Dec 1, 1991·Bone and Mineral·J W DavisR D Wasnich
Jan 1, 1991·Calcified Tissue International·S R Cummings
Mar 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R R Recker, R P Heaney
Jul 1, 1990·American Journal of Public Health·S J JacobsenA A Rimm
Feb 17, 1989·JAMA : the Journal of the American Medical Association·N M Resnick, S L Greenspan
Oct 1, 1989·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P D RossJ M Vogel
Sep 1, 1989·Annals of Internal Medicine·S L HuiC C Johnston
Jun 1, 1989·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J W DavisJ M Vogel
Aug 1, 1989·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R P HeaneyA J Moy
Jun 1, 1987·American Journal of Obstetrics and Gynecology·M E QuigleyP Brooks
Nov 1, 1985·Journal of the American Geriatrics Society·D Rudman
Dec 1, 1985·American Journal of Obstetrics and Gynecology·R D WasnichJ M Vogel
Jun 1, 1984·The Journal of Clinical Investigation·K S TsaiB L Riggs
Oct 1, 1984·The Journal of Clinical Endocrinology and Metabolism·A E BennettR L Hintz
Dec 1, 1984·American Journal of Public Health·M E FarmerK R Bailey
May 1, 1984·American Journal of Epidemiology·K YanoL K Heilbrun
Jan 1, 1982·Journal of Chronic Diseases·S L HuiC C Johnston
May 1, 1981·The Journal of Clinical Investigation·D RudmanR P Bain
Nov 1, 1994·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M C NevittS R Cummings
Dec 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S L GreenspanT H Kido
Oct 14, 1993·The New England Journal of Medicine·D T FelsonJ J Anderson
May 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D T FelsonJ J Anderson

❮ Previous
Next ❯

Citations

Jan 1, 1997·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Jul 3, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·L ReiderUNKNOWN Study of Osteoporotic Fractures Research Group
Sep 13, 2008·Calcified Tissue International·Gregory J TranahUNKNOWN Study of Osteoporotic Fractures (SOF) Research Group
Sep 25, 2008·Calcified Tissue International·Elaine W YuDouglas C Bauer
Apr 2, 2011·Calcified Tissue International·Susan J DiemUNKNOWN Study of Osteoporotic Fractures Research Group
Aug 2, 2002·Obstetrics and Gynecology·Noel S Weiss, Miriam M Treggiari
Jul 27, 2000·Obstetrics and Gynecology·L WeinsteinC Bourguignon
Jun 24, 2003·Maturitas·Joonas SirolaUNKNOWN OSTPRE Study Group
Jul 21, 1998·Endocrinology and Metabolism Clinics of North America·P D Ross
May 1, 1997·Trends in Endocrinology and Metabolism : TEM·S Epstein, P Miller
Feb 13, 1999·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·N TangsinmankongR A Good
Jan 26, 2002·Joint, Bone, Spine : Revue Du Rhumatisme·C CormierA Kahan
Aug 4, 2011·European Journal of Clinical Nutrition·L T Ho-PhamT V Nguyen
Sep 4, 1997·The New England Journal of Medicine·B Dawson-HughesG E Dallal
Mar 27, 2001·Journal of Women's Health & Gender-based Medicine·G A KuchelN M Resnick
Jul 19, 2011·Annals of Human Genetics·Yan GuoHong-Wen Deng
Feb 24, 2007·BMC Musculoskeletal Disorders·Tuan V NguyenMarkus J Seibel
Nov 30, 2000·Arthritis Research·D J Hunter, P N Sambrook
Mar 6, 2008·The Journal of Clinical Endocrinology and Metabolism·S P MoffettUNKNOWN Study of Osteoporotic Fractures Research Group
Feb 25, 2011·The Journal of Clinical Endocrinology and Metabolism·Braxton D Mitchell, Laura M Yerges-Armstrong
Jun 17, 2011·The Journal of Clinical Endocrinology and Metabolism·M O PremaorUNKNOWN Study of Osteoporotic Fractures
Oct 3, 1999·Journal of Periodontology·R J WeyantJ A Cauley
Sep 10, 2011·Journal of Osteoporosis·Joonas Sirola, Heikki Kröger
Apr 12, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Kamil E BarbourUNKNOWN Study of Osteoporotic Fractures (SOF) Research Group
Mar 1, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kouta ItoElena B Elkin
Oct 16, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J T SchousboeK E Ensrud
Jan 6, 2018·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Panagiotis KerezoudisMohamad Bydon
Feb 21, 2018·Menopause : the Journal of the North American Menopause Society·Gina N WoodsUNKNOWN Study of Osteoporotic Fractures (SOF) Research Group
Aug 15, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Melissa PremaorUNKNOWN Study of Osteoporotic Fractures (SOF) Research Group
Feb 15, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Brian Louis McNabbDennis M Black
Apr 26, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M T HannanD P Kiel
Nov 4, 2008·Journal of Bone and Mineral Metabolism·Lian-Hua CuiJeong-Soo Im
Jan 14, 2009·Calcified Tissue International·C DierkesL Fink
Jul 15, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M LateefA Azhar
Nov 26, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·L A AhmedR M Joakimsen
Dec 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Z H HanA M Parfitt
Oct 25, 2017·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A M RathbunM C Hochberg
Jan 13, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S YangT V Nguyen

❮ Previous
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