HIP (HPA-screening in pregnancy) study: protocol of a nationwide, prospective and observational study to assess incidence and natural history of fetal/neonatal alloimmune thrombocytopenia and identifying pregnancies at risk.

BMJ Open
Dian WinkelhorstMasja de Haas

Abstract

Fetal and neonatal alloimmune thrombocytopenia (FNAIT) may lead to severe fetal or neonatal bleeding and/or perinatal death. Maternal alloantibodies, targeted against fetal human platelet antigens (HPAs), can result thrombocytopenia and bleeding complications. In pregnancies with known immunisation, fetal bleeding can be prevented by weekly maternal intravenous immunoglobulin infusions. Without population-based screening, immunisation is only detected after birth of an affected infant. Affected cases that might have been prevented, when timely identified through population-based screening. Implementation is hampered by the lack of knowledge on incidence, natural history and identification of pregnancies at high risk of bleeding. We designed a study aimed to obtain this missing knowledge. The HIP (HPA-screening in pregnancy) study is a nationwide, prospective and observational cohort study aimed to assess incidence and natural history of FNAIT as well as identifying pregnancies at high risk for developing bleeding complications. For logistic reasons, we invite rhesus D-negative or rhesus c-negative pregnant women, who take part in the Dutch population-based prenatal screening programme for erythrocyte immunisation, to participat...Continue Reading

Associated Clinical Trials

References

Mar 1, 1990·American Journal of Obstetrics and Gynecology·R F Burrows, J G Kelton
Feb 1, 1990·British Journal of Haematology·V S BlanchetteF Décary
Feb 18, 1989·Lancet·C Mueller-EckhardtS Santoso
Apr 10, 1995·Physical Review Letters· van der Ploeg H van der Woude A
May 14, 2003·BJOG : an International Journal of Obstetrics and Gynaecology·Anne DavorenWilliam G Murphy
Dec 11, 2008·Pediatric Neurology·Surya N GuptaUday S Kanamalla
Sep 5, 2009·Current Opinion in Hematology·Anne HusebekkBjørn Skogen
Jul 14, 2010·BJOG : an International Journal of Obstetrics and Gynaecology·M M KamphuisD Oepkes
Sep 8, 2012·Current Opinion in Hematology·Jens Kjeldsen-KraghBjørn Skogen
Apr 23, 2015·Vox Sanguinis·M de HaasC E van der Schoot
Apr 13, 2017·Acta Obstetricia Et Gynecologica Scandinavica·Dian WinkelhorstDick Oepkes

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Methods Mentioned

BETA
ELISA
PCR
glycosylation

Software Mentioned

Graphpad
SPSS
PASS
ProMISe Manager
ProMISe

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