Hip joint replacement surgery for idiopathic osteoarthritis aggregates in families

Arthritis Research & Therapy
H BukulmezM L Warman

Abstract

In order to determine whether there is a genetic component to hip or knee joint failure due to idiopathic osteoarthritis (OA), we invited patients (probands) undergoing hip or knee arthroplasty for management of idiopathic OA to provide detailed family histories regarding the prevalence of idiopathic OA requiring joint replacement in their siblings. We also invited their spouses to provide detailed family histories about their siblings to serve as a control group. In the probands, we confirmed the diagnosis of idiopathic OA using American College of Rheumatology criteria. The cohorts included the siblings of 635 probands undergoing total hip replacement, the siblings of 486 probands undergoing total knee replacement, and the siblings of 787 spouses. We compared the prevalence of arthroplasty for idiopathic OA among the siblings of the probands with that among the siblings of the spouses, and we used logistic regression to identify independent risk factors for hip and knee arthroplasty in the siblings. Familial aggregation for hip arthroplasty, but not for knee arthroplasty, was observed after controlling for age and sex, suggesting a genetic contribution to end-stage hip OA but not to end-stage knee OA. We conclude that attempt...Continue Reading

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Citations

Jun 13, 2009·Arthritis Research & Therapy·Mary B Goldring, Kenneth B Marcu
Nov 17, 2010·Nature Reviews. Rheumatology·Ana M Valdes, Tim D Spector
Sep 6, 2007·Journal of Cellular Physiology·Mary B Goldring, Steven R Goldring
Feb 5, 2010·Arthritis and Rheumatism·Sebastian Koelling, Nicolai Miosge

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Methods Mentioned

BETA
bilateral arthroplasty

Software Mentioned

SAGE SAGE
SAS
SEGREG

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