Hippo pathway affects survival of cancer patients: extensive analysis of TCGA data and review of literature.

Scientific Reports
Anello Marcello PomaGabriella Fontanini

Abstract

The disruption of the Hippo pathway occurs in many cancer types and is associated with cancer progression. Herein, we investigated the impact of 32 Hippo genes on overall survival (OS) of cancer patients, by both analysing data from The Cancer Genome Atlas (TCGA) and reviewing the related literature. mRNA and protein expression data of all solid tumors except pure sarcomas were downloaded from TCGA database. Thirty-two Hippo genes were considered; for each gene, patients were dichotomized based on median expression value. Survival analyses were performed to identify independent predictors, taking into account the main clinical-pathological features affecting OS. Finally, independent predictors were correlated with YAP1 oncoprotein expression. At least one of the Hippo genes is an independent prognostic factor in 12 out of 13 considered tumor datasets. mRNA levels of the independent predictors coherently correlate with YAP1 in glioma, kidney renal clear cell, head and neck, and bladder cancer. Moreover, literature data revealed the association between YAP1 levels and OS in gastric, colorectal, hepatocellular, pancreatic, and lung cancer. Herein, we identified cancers in which Hippo pathway affects OS; these cancers should be can...Continue Reading

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Citations

Jul 28, 2019·Journal of Cellular Physiology·Fatemeh RafieeniaSeyed Hamid Aghaee-Bakhtiari
Dec 13, 2019·Wiley Interdisciplinary Reviews. Developmental Biology·Benjamin J van Soldt, Wellington V Cardoso
Oct 25, 2020·Journal of Cancer Research and Clinical Oncology·Richard DrexlerKarl J Oldhafer
May 27, 2021·PLoS Computational Biology·Halil İbrahim KuruOznur Tastan
Aug 17, 2021·Frontiers in Oncology·Hiromitsu HayashiHideo Baba

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Software Mentioned

R
powerSurvEpi R
Hmisc R package

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