Hippo signaling in regeneration and aging.

Mechanisms of Ageing and Development
Dana Elster, Björn von Eyss

Abstract

The two transcriptional coactivators YAP/TAZ act as the downstream transducers of the Hippo pathway. Recent studies have demonstrated that those two transcriptional regulators are crucial for an organism in order to induce a regenerative response upon tissue damage. In addition, YAP/TAZ are promising targets for regenerative medicine, as artificially increasing YAP/TAZ activity can be used to stimulate tissue regeneration, even in tissues that otherwise have little ability to regenerate. We will summarize here how YAP/TAZ could be used in regenerative medicine and how these two transcriptional regulators have been linked to aging so far.

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Citations

Apr 9, 2021·Journal of Proteomics·Murugesan PooranachithraKrishnaswamy Balamurugan

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