Hippocampal 3alpha,5alpha-THP may alter depressive behavior of pregnant and lactating rats

Pharmacology, Biochemistry, and Behavior
Cheryl A Frye, A A Walf

Abstract

The 5alpha-reduced metabolite of progesterone (P), 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP), may mediate progestins' effects to reduce depressive behavior of female rats in part through actions in the hippocampus. To investigate, forced swim test behavior and plasma and hippocampal progestin levels were assessed in groups of rats expected to differ in their 3alpha,5alpha-THP levels due to endogenous differences (pregnant and postpartum), administration of a 5alpha-reductase inhibitor (finasteride; 50 mg/kg sc), and/or gestational stress [prenatal stress (PNS)], an animal model of depression. Pregnant rats had higher plasma and hippocampal 3alpha,5alpha-THP levels and less depressive behavior (decreased immobility, increased struggling and swimming) in the forced swim test than did postpartum rats. Finasteride, compared to vehicle-administration, reduced plasma and hippocampal 3alpha,5alpha-THP levels and increased depressive behavior (increased immobility, decreased struggling and swimming). PNS was associated with lower hippocampal, but not plasma, 3alpha,5alpha-THP levels and increased swimming compared to that observed in control rats. Together, these data suggest that 3alpha,5alpha-THP in the hippocampus may medi...Continue Reading

References

Jan 1, 1991·Journal of Child Psychology and Psychiatry, and Allied Disciplines·J McGuire, F Earls
Mar 1, 1991·Neurotoxicology and Teratology·L A Pohorecky, P Roberts
Aug 1, 1990·Physiology & Behavior·A Wakshlak, M Weinstock
Jan 1, 1987·Psychopharmacology·W B MendelsonS M Paul
Mar 1, 1987·Psychological Bulletin·S Nolen-Hoeksema
May 1, 1986·Developmental Psychobiology·C L Moore, K L Power
Oct 1, 1982·Pharmacology, Biochemistry, and Behavior·D A Peters
Aug 11, 1995·Science·M M Weissman, M Olfson
Dec 1, 1994·Hormones and Behavior·N C Lan, K W Gee
Mar 1, 1994·Pharmacology, Biochemistry, and Behavior·B ZimmerbergM A Hofer
Aug 1, 1993·Physiology & Behavior·E L Abel
Jan 1, 1996·Pharmacology, Biochemistry, and Behavior·C A Frye, J E Duncan
Dec 1, 1996·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·V K PatchevO F Almeida
Jan 22, 1998·The New England Journal of Medicine·P J SchmidtD R Rubinow
Apr 18, 1998·Proceedings of the National Academy of Sciences of the United States of America·V UzunovaA Guidotti
Mar 20, 1998·Journal of Abnormal Psychology·P M LewinsohnN B Allen
May 20, 1998·Pharmacology, Biochemistry, and Behavior·B Zimmerberg, L G Blaskey
Oct 24, 1998·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·B Zimmerberg, R C Brown
Nov 13, 1998·Proceedings of the National Academy of Sciences of the United States of America·I M RachmanR S Cohen

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Citations

Oct 27, 2005·Psychopharmacology·Veska UzunovaDoncho P Uzunov
Mar 24, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Alicia A Walf, Cheryl A Frye
May 28, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Virginia L BrooksCheryl M Heesch
Sep 28, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Lyudmyla KvochinaCheryl M Heesch
Oct 13, 2006·Neuroimmunomodulation·Siobhain M O'MahonyBrian E Leonard
Apr 9, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·Jason J Paris, Cheryl A Frye
Jan 20, 2007·Cellular and Molecular Neurobiology·Erin M MacKenzieGlen B I Baker
Nov 13, 2010·Autonomic Neuroscience : Basic & Clinical·Cheryl M Heesch
Oct 16, 2007·Physiology & Behavior·Alicia A Walf, Cheryl A Frye
Jul 13, 2006·CNS Drug Reviews·Deborah A FinnKristine M Wiren
Feb 17, 2010·Physiology & Behavior·S AndradeM F M Ribeiro
Jul 15, 2004·Pharmacology, Biochemistry, and Behavior·Cheryl A Frye, Kassandra L Edinger
Aug 2, 2005·Epilepsy & Behavior : E&B·Madeline E RhodesCheryl A Frye
Sep 30, 2014·CNS Spectrums·Crystal Edler SchillerDavid R Rubinow
Sep 6, 2005·Hormones and Behavior·Karin J BodensteinerLyndsey A Hamula
Jul 3, 2007·Frontiers in Neuroendocrinology·Joseph S Lonstein
Jul 7, 2007·Stress : the International Journal on the Biology of Stress·Alicia A Walf, Cheryl A Frye
Jan 30, 2016·Journal of Experimental Neuroscience·Darryl J MayeauxMatthew J Fitzharris
Mar 10, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Alicia A Walf, Cheryl A Frye
Dec 13, 2007·Nature Reviews. Neuroscience·Paula J Brunton, John A Russell
Jul 31, 2014·Journal of Neuroendocrinology·J S LonsteinI D Neumann
Nov 12, 2019·Neurobiology of Stress·Najah Walton, Jamie Maguire
Mar 8, 2011·Hormones and Behavior·Jodi L PawluskiHarry W M Steinbusch
May 22, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Shiyi ChenYiping Ye

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