Hippocampal 5-HT7 receptors signal phosphorylation of the GluA1 subunit to facilitate AMPA receptor mediated-neurotransmission in vitro and in vivo

British Journal of Pharmacology
Filippo AndreettaNicholas M Barnes

Abstract

The 5-HT7 receptor is a GPCR that is the target of a broad range of antidepressant and antipsychotic drugs. Various studies have demonstrated an ability of the 5-HT7 receptor to modulate glutamatergic neurotransmission and cognitive processes although the potential impact upon AMPA receptors has not been investigated directly. The purposes of the present study were to investigate a direct modulation of the GluA1 AMPA receptor subunit and determine how this might influence AMPA receptor function. The influence of pharmacological manipulation of the 5-HT7 receptor system upon phosphorylation of GluA1 subunits was assessed by Western blotting of fractionated proteins from hippocampal neurones in culture (or proteins resident at the neurone surface) and the functional impact assessed by electrophysiological recordings in rat hippocampus in vitro and in vivo. 5-HT7 receptor activation increased cAMP and relative pCREB levels in cultures of rat hippocampal neurones along with an increase in phosphorylation (Ser845) of the GluA1 AMPA receptor subunit evident in whole neurone extracts and within the neurone surface compartment. Electrophysiological recordings in rat hippocampus demonstrated a 5-HT7 receptor-mediated increase in AMPA re...Continue Reading

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Citations

Jan 17, 2020·International Journal of Molecular Sciences·Marianna CrispinoCarla Perrone-Capano
Mar 28, 2017·Reviews in the Neurosciences·Alfredo Meneses
Aug 14, 2018·Pharmacological Reports : PR·Dasiel O Borroto-EscuelaKjell Fuxe
Mar 3, 2021·Cellular and Molecular Neurobiology·Mahsa PourhamzehMohammad Taghi Joghataei
Sep 1, 2018·Pharmacological Reports : PR·Dasiel O Borroto-EscuelaKjell Fuxe
Apr 4, 2017·Experimental Neurology·Edward W VogelBarclay Morrison

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